Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 792870..793511 Replicon chromosome
Accession NZ_CP019672
Organism Burkholderia cenocepacia strain VC12308

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag A8E75_RS03765 Protein ID WP_077190809.1
Coordinates 793173..793511 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag A8E75_RS03760 Protein ID WP_006490972.1
Coordinates 792870..793169 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8E75_RS03735 788103..789374 + 1272 WP_077190813.1 Rieske 2Fe-2S domain-containing protein -
A8E75_RS03740 789390..789866 + 477 WP_077190812.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
A8E75_RS03745 789902..790228 + 327 WP_077190811.1 non-heme iron oxygenase ferredoxin subunit -
A8E75_RS03750 790218..791438 + 1221 WP_077190810.1 FAD-dependent oxidoreductase -
A8E75_RS03755 791535..792821 + 1287 WP_048988716.1 DUF445 domain-containing protein -
A8E75_RS03760 792870..793169 - 300 WP_006490972.1 putative addiction module antidote protein Antitoxin
A8E75_RS03765 793173..793511 - 339 WP_077190809.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A8E75_RS03770 793879..795519 + 1641 WP_006490980.1 acetolactate synthase large subunit -
A8E75_RS03775 795548..796981 + 1434 WP_006490987.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(16-109)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12600.50 Da        Isoelectric Point: 7.8814

>T73153 WP_077190809.1 NZ_CP019672:c793511-793173 [Burkholderia cenocepacia]
MVDTLQCTPYSPPAFSIRTIDVFDAWFAGLPDRLAKRRIQARIDRLPMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRG
TIWVILLCGGDQSTQQADIRAAHAMLAHLDME

Download         Length: 339 bp

>T73153 NZ_CP019672:c793511-793173 [Burkholderia cenocepacia]
ATGGTTGACACATTGCAATGCACGCCCTACAGTCCTCCTGCATTCAGCATCCGGACCATCGACGTCTTCGACGCCTGGTT
TGCCGGCCTGCCCGATCGCCTCGCCAAACGCCGCATCCAGGCGCGCATCGACCGCCTGCCGATGGGCAATCCGGGCGACT
GGAAATCCGCCGGCTCCCCCGTCGTCGAAATGCGTATCGACCACGGCCCGGGCTATCGCGTCTATTACGTGAGGCGCGGA
ACGATATGGGTCATCCTGCTGTGCGGCGGCGATCAATCGACGCAACAGGCCGACATCCGCGCCGCGCACGCAATGCTCGC
GCACCTCGACATGGAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10608.04 Da        Isoelectric Point: 6.4771

>AT73153 WP_006490972.1 NZ_CP019672:c793169-792870 [Burkholderia cenocepacia]
MDKIKTRPWDSAEHLKTEDDMADYFDACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAAA

Download         Length: 300 bp

>AT73153 NZ_CP019672:c793169-792870 [Burkholderia cenocepacia]
ATGGACAAGATCAAGACGCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGAAGACGACATGGCCGACTACTTCGACGC
ATGCCTGCAGGAGGCCGGCGACGATCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCCCGTGCACGCGGCATGTCGC
AGGTCGCACGCGATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTCATCAAGGCGCTCGGCCTGCAATTGCACGGCGCCAAGGCTGCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References