73149

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 3909924..3910963 Replicon chromosome
Accession NZ_CP019670
Organism Burkholderia cenocepacia strain VC12802

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag A8E96_RS23120 Protein ID WP_077219154.1
Coordinates 3909924..3910499 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag A8E96_RS23125 Protein ID WP_077219153.1
Coordinates 3910496..3910963 (-) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8E96_RS23105 3905673..3907445 + 1773 WP_012338278.1 iron ABC transporter permease -
A8E96_RS23110 3907438..3908505 + 1068 WP_077219156.1 ABC transporter ATP-binding protein -
A8E96_RS23115 3908658..3909749 + 1092 WP_077219155.1 porin -
A8E96_RS23120 3909924..3910499 - 576 WP_077219154.1 PIN domain-containing protein Toxin
A8E96_RS23125 3910496..3910963 - 468 WP_077219153.1 helix-turn-helix domain-containing protein Antitoxin
A8E96_RS23130 3911147..3912106 - 960 WP_077219152.1 zinc-binding alcohol dehydrogenase family protein -
A8E96_RS23135 3912139..3912390 - 252 WP_006479165.1 hypothetical protein -
A8E96_RS23140 3912486..3913277 + 792 WP_077219151.1 helix-turn-helix transcriptional regulator -
A8E96_RS23145 3913353..3914159 - 807 WP_077219150.1 4-hydroxy-2-oxoheptanedioate aldolase -
A8E96_RS23150 3914172..3914975 - 804 WP_006479168.1 2-oxo-hepta-3-ene-1,7-dioic acid hydratase -
A8E96_RS23155 3914996..3915388 - 393 WP_027811930.1 5-carboxymethyl-2-hydroxymuconate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21536.88 Da        Isoelectric Point: 6.4779

>T73149 WP_077219154.1 NZ_CP019670:c3910499-3909924 [Burkholderia cenocepacia]
MTSSPFTAVYDACVLYPAPLRDFLMWLALSGCFRARWSADIHNEWKRNLLRKRVDLSAAQLDRTASLMDRAIPDALVTGY
EALIEGLRLPDADDRHVLAAAIRCNASVIVTFNQKDFPDAVLSTYGVEAQHPDVFVDNLFDLEPAAVVGAARRQREMLKH
PPMMVDRYLDILQRQGMVQTCKALEAYRAIL

Download         Length: 576 bp

>T73149 NZ_CP019670:c3910499-3909924 [Burkholderia cenocepacia]
ATGACGAGTTCGCCATTCACGGCGGTCTATGATGCCTGCGTGCTGTACCCGGCCCCGCTACGCGATTTCCTGATGTGGCT
CGCATTGAGCGGATGTTTCAGGGCTCGCTGGAGTGCCGATATCCACAACGAATGGAAACGGAATCTGCTGCGCAAGCGCG
TGGACCTCAGTGCCGCGCAACTCGACCGTACCGCGAGTCTGATGGATCGGGCGATACCTGATGCGCTGGTGACCGGGTAC
GAAGCGCTGATCGAGGGCCTGAGGTTGCCGGATGCTGATGATCGGCATGTCCTGGCCGCCGCGATCCGCTGCAACGCCAG
TGTGATCGTGACGTTCAATCAGAAGGACTTTCCCGACGCAGTGCTGTCGACGTATGGGGTGGAAGCGCAGCATCCCGACG
TATTCGTCGACAATCTCTTCGATCTCGAGCCGGCTGCGGTTGTCGGCGCGGCACGGCGACAACGCGAAATGCTCAAGCAT
CCTCCGATGATGGTGGACCGCTACCTCGACATCCTGCAGCGGCAGGGCATGGTTCAGACCTGCAAGGCGCTCGAAGCTTA
CCGGGCGATTCTTTGA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17461.86 Da        Isoelectric Point: 6.2305

>AT73149 WP_077219153.1 NZ_CP019670:c3910963-3910496 [Burkholderia cenocepacia]
MPHTSMSDTILPVEREVQAAVEGQRALAAYLATRTEIQRIQIFDDDNRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESKALPYHKTGKHRRVRFSDLMRYKTEREQASASAMEELSRQAQEFGMGYE

Download         Length: 468 bp

>AT73149 NZ_CP019670:c3910963-3910496 [Burkholderia cenocepacia]
ATGCCCCATACCTCGATGTCCGATACGATCTTGCCGGTGGAGCGCGAGGTGCAGGCGGCTGTCGAAGGCCAGCGTGCGCT
GGCGGCTTATCTGGCCACGCGAACGGAAATACAGCGCATCCAGATTTTCGATGACGACAATCGTGCGCATCAGGTCGAGC
TTCCGACTTCTGCGCTGCGTCTGTTGGTCGACATCCTCGCGGAGCTTGCAGATGGCAACGCGGTCAAGGTCGTGCCCGTT
CATGCGGAACTAACCACGCAGGAAGCAGCCGACCTGCTCAATGTGTCCCGTCCACACCTGATCAAGCTGCTCGAATCGAA
GGCGCTGCCGTATCACAAGACTGGCAAGCACCGTCGTGTGCGCTTTTCCGATCTGATGCGTTACAAGACCGAACGCGAGC
AGGCGAGCGCCAGTGCGATGGAAGAGTTGAGTCGGCAAGCGCAGGAGTTCGGGATGGGCTACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References