Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3356738..3358503 Replicon chromosome
Accession NZ_CP019670
Organism Burkholderia cenocepacia strain VC12802

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag A8E96_RS20655 Protein ID WP_077218675.1
Coordinates 3356738..3357649 (+) Length 304 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1K294
Locus tag A8E96_RS20660 Protein ID WP_011547426.1
Coordinates 3357646..3358503 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8E96_RS20625 3352109..3353188 - 1080 WP_027805911.1 porin -
A8E96_RS20630 3353633..3353950 + 318 WP_077218672.1 non-heme iron oxygenase ferredoxin subunit -
A8E96_RS20635 3353952..3354263 + 312 WP_006478722.1 hypothetical protein -
A8E96_RS20640 3354324..3355394 + 1071 WP_077218673.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
A8E96_RS20645 3355387..3356157 + 771 WP_077218674.1 SDR family oxidoreductase -
A8E96_RS20650 3356192..3356719 + 528 WP_011547424.1 cupin domain-containing protein -
A8E96_RS20655 3356738..3357649 + 912 WP_077218675.1 alpha/beta hydrolase Toxin
A8E96_RS20660 3357646..3358503 + 858 WP_011547426.1 IclR family transcriptional regulator Antitoxin
A8E96_RS20665 3358500..3359297 + 798 WP_077218676.1 SDR family oxidoreductase -
A8E96_RS20670 3359290..3360957 + 1668 WP_077218677.1 thiamine pyrophosphate-binding protein -
A8E96_RS20675 3360950..3361777 + 828 WP_077218678.1 aspartate dehydrogenase -
A8E96_RS20680 3361850..3363340 + 1491 WP_077218679.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(56-284)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 304 a.a.        Molecular weight: 30948.29 Da        Isoelectric Point: 7.3264

>T73147 WP_077218675.1 NZ_CP019670:3356738-3357649 [Burkholderia cenocepacia]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAGEAGAQHAGRALPVVLLHGIGSGAASWVCQLDTLGASR
RVLAWDAPGYGVSTPVPGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLVRVMPARIAGLLLISPAGGYGSA
PAETRESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEEAKAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRT
AVAVGANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDTFCRQCDPQRGLA

Download         Length: 912 bp

>T73147 NZ_CP019670:3356738-3357649 [Burkholderia cenocepacia]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCAGCGTTG
CGCGGCCGGCGCGGCTGGCACGATCGGCTACCGTGAGGCGGGGGCAGGCGAGGCCGGCGCGCAGCATGCGGGCCGTGCGC
TGCCCGTCGTGCTGCTGCACGGGATCGGTTCGGGCGCCGCATCGTGGGTCTGCCAGCTCGATACGCTGGGTGCATCGCGG
CGCGTGCTCGCGTGGGACGCGCCCGGTTACGGCGTGTCGACGCCCGTGCCCGGCGCGTCGCCGGCCGCCGCCGATTACGC
GGCATCGCTGAACGCGTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGATCATCG
CGGGCGGCCTCGTCCGCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGATTTCGCCCGCGGGCGGCTACGGCAGCGCA
CCGGCCGAGACCCGCGAATCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGCCCGGCCGGGCTCGCCGAGCA
GCGCAGCGGCAACATGCTGTCCGGCTTCGCGAACGAGGAGGCAAAGGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGC
CGGCCGGCTACGCGCAGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGGCCGATCTCGCCGGCTTTCGCGGCCGCACG
GCCGTGGCCGTCGGCGCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGCT
GCAGGTGATTCCGCAGGCGGGGCATGCCGGCTACGTGGAAGCGCCGGCCGTTTATTCCGCGCTGATCGACACGTTCTGTC
GTCAGTGCGACCCACAGCGGGGACTGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31315.76 Da        Isoelectric Point: 6.5054

>AT73147 WP_011547426.1 NZ_CP019670:3357646-3358503 [Burkholderia cenocepacia]
MSEPLQQNESDNAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGALNRMTSATPETVDALYDVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT73147 NZ_CP019670:3357646-3358503 [Burkholderia cenocepacia]
ATGAGCGAACCGCTGCAACAAAACGAATCCGACAACGCGAAGGCCGAAGCCAGCTATGTGGTGCCGGGCCTCGAACGCGG
GCTGCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCCGAATTGTCGAAACGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGTTTTCTCGAACGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGTTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGA
GAGCCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATTCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACCCGGCTGCCCGCGCACGCGACGACGCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAACTGCACGCGCTGTATCCGGAAGGCGCGCTGAACCGGATGACGAGCGCAAC
GCCGGAAACGGTCGACGCGCTGTACGACGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGGATCTCGGTCGTCACGGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGTCCGGAGATCGACGCGGCGCTGATCGCGGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAATTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTCTCAAAGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B1K294

References