Detailed information of TA system TA073146

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 3133650..3134173
• Replicon: chromosome
• Accession: NZ_CP019670
• Organism: Burkholderia cenocepacia strain VC12802

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: A8E96_RS19585
• Protein ID: WP_011547274.1
• Coordinates: 3133650..3133916 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1K8I6
• Locus tag: A8E96_RS19590
• Protein ID: WP_011547275.1
• Coordinates: 3133913..3134173 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8E96_RS19560	3128948..3130186	-	1239	WP_077220588.1	diaminopimelate decarboxylase	-
A8E96_RS19565	3130295..3131209	+	915	WP_077220589.1	LysR family transcriptional regulator	-
A8E96_RS19570	3131270..3131869	+	600	WP_012339671.1	GNAT family N-acetyltransferase	-
A8E96_RS19575	3131991..3132569	-	579	WP_027806940.1	DUF4142 domain-containing protein	-
A8E96_RS19580	3132977..3133600	-	624	WP_006480833.1	HAD hydrolase-like protein	-
A8E96_RS19585	3133650..3133916	-	267	WP_011547274.1	Txe/YoeB family addiction module toxin	Toxin
A8E96_RS19590	3133913..3134173	-	261	WP_011547275.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
A8E96_RS19595	3134405..3134848	+	444	WP_077220590.1	GNAT family N-acetyltransferase	-
A8E96_RS19600	3134906..3135124	+	219	WP_006480837.1	DUF1653 domain-containing protein	-
A8E96_RS19605	3135147..3135605	-	459	WP_027806937.1	ATP synthase F1 subunit epsilon	-
A8E96_RS19610	3135616..3136491	-	876	WP_077220645.1	ATP synthase F1 subunit gamma	-
A8E96_RS19615	3136639..3137610	+	972	WP_077220591.1	phosphate acetyltransferase	-
A8E96_RS19620	3137621..3138829	+	1209	WP_077220592.1	acetate/propionate family kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10556.88 Da
• Isoelectric Point: 7.9861

>T73146 WP_011547274.1 NZ_CP019670:c3133916-3133650 [Burkholderia cenocepacia]
MSVRRVLFTSDAWDDYVYWQGQDRKTLKRINQLIRETQRTPFEGIGKPEPLKANLSGFWSRRIDDTNRLVYEADDLQISI
VSCRYHYE

Nucleotide

• Length: 267 bp

>T73146 NZ_CP019670:c3133916-3133650 [Burkholderia cenocepacia]
ATGAGCGTACGTCGCGTGCTCTTTACTTCCGACGCATGGGATGACTATGTCTACTGGCAAGGACAGGATCGCAAGACGCT
CAAGCGCATCAACCAGCTCATTCGCGAAACCCAGCGCACGCCGTTCGAAGGCATCGGCAAGCCGGAGCCGTTGAAAGCCA
ATCTCTCCGGCTTCTGGTCGCGCCGTATCGACGATACGAATCGCCTGGTCTACGAGGCTGACGACCTTCAAATCAGCATC
GTGTCCTGTCGCTACCATTACGAGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9745.00 Da
• Isoelectric Point: 6.0717

>AT73146 WP_011547275.1 NZ_CP019670:c3134173-3133913 [Burkholderia cenocepacia]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQDYYDSLMETVHLLRSPANVAHLERSIAQLRKGKAKEHK
LAEDDE

Nucleotide

• Length: 261 bp

>AT73146 NZ_CP019670:c3134173-3133913 [Burkholderia cenocepacia]
ATGCGCACGATTCATTTTTCCGATGCCCGCGGCAATCTGAAGACCGTCATCGACCAGGTCGTCGACGATGCGGACGTGAC
GCTCATTACGCGCCGCGATGCACCGAACGCCGTCATCATGTCGCAGGACTATTACGACAGCCTGATGGAGACGGTCCACT
TGCTGCGCTCGCCAGCCAACGTCGCTCATCTCGAACGTTCGATCGCGCAACTGCGCAAGGGCAAGGCGAAAGAACACAAG
CTCGCCGAGGATGATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1J9NJ62