Detailed information of TA system TA073145

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3057301..3058527
• Replicon: chromosome
• Accession: NZ_CP019670
• Organism: Burkholderia cenocepacia strain VC12802

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: A8E96_RS19225
• Protein ID: WP_077220547.1
• Coordinates: 3057301..3057882 (-)
• Length: 194 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: A8E96_RS19230
• Protein ID: WP_077220548.1
• Coordinates: 3057961..3058527 (-)
• Length: 189 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8E96_RS19210	3053641..3055695	-	2055	WP_077220546.1	MacB family efflux pump subunit	-
A8E96_RS19215	3055698..3056891	-	1194	WP_077220641.1	efflux RND transporter periplasmic adaptor subunit	-
A8E96_RS19225	3057301..3057882	-	582	WP_077220547.1	HD domain-containing protein	Toxin
A8E96_RS19230	3057961..3058527	-	567	WP_077220548.1	helix-turn-helix domain-containing protein	Antitoxin
A8E96_RS19235	3058976..3060379	+	1404	WP_077220549.1	hypothetical protein	-
A8E96_RS19240	3060479..3061057	+	579	WP_077220550.1	hypothetical protein	-
A8E96_RS19245	3061185..3061916	+	732	WP_027811744.1	ribonuclease T2	-
A8E96_RS19250	3061942..3062595	-	654	WP_077220551.1	cysteine hydrolase	-
A8E96_RS19255	3062835..3063446	+	612	WP_077220552.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-171)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 194 a.a.
• Molecular weight: 21359.16 Da
• Isoelectric Point: 5.5671

>T73145 WP_077220547.1 NZ_CP019670:c3057882-3057301 [Burkholderia cenocepacia]
MNPETIHARLAFLREAERLKDVLRSGHTSAGRPESTAEHSWRLCLMALVFADALPGVDALKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLMLTASLDRAVRDEIVALWDEYEAAASPEARAAKALDKLETILQHNQGCNPPDFDYAFNLGY
GRRYTDAAPLFRAIREIVDADTQRKIDAGGRRA

Nucleotide

• Length: 582 bp

>T73145 NZ_CP019670:c3057882-3057301 [Burkholderia cenocepacia]
ATGAACCCCGAGACGATCCACGCGCGGCTCGCGTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGCCGCCCGGAAAGCACGGCCGAGCACAGCTGGCGGCTATGCCTGATGGCGCTCGTGTTCGCCGACGCAC
TGCCCGGCGTCGACGCGCTGAAGCTGCTGAAACTGTGCGTCGTCCACGACCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCATCCCGACAAGAGCGCACATGAACGCGACGACCTGCTGATGCTGACCGCGTCGCTCGACCG
CGCGGTGCGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGGCGGCCGCCTCACCCGAAGCCCGCGCGGCGAAGGCGC
TCGACAAGCTCGAAACGATCCTGCAGCACAACCAGGGGTGCAATCCGCCCGATTTCGACTATGCGTTCAACCTCGGCTAC
GGCCGGCGCTATACCGACGCCGCGCCGCTGTTCCGCGCGATCCGCGAGATCGTCGACGCCGATACGCAGCGCAAGATCGA
CGCGGGTGGACGCCGCGCATAG

Antitoxin

Protein

• Length: 189 a.a.
• Molecular weight: 20475.38 Da
• Isoelectric Point: 10.7076

>AT73145 WP_077220548.1 NZ_CP019670:c3058527-3057961 [Burkholderia cenocepacia]
MPHPPLHPSSLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGLQQMSPAERATAERLLAARLDSAGDHALARLIAG
SAGRMHLVCDLTHRLLASSPARAAEFSQPLSTLLGTSLWRYATPEIVRMEAALDALGWHDRAGPPSVEFDTGANASRVVP
IRGSRCRWTRMTLSDGSAVRLVETLDAH

Nucleotide

• Length: 567 bp

>AT73145 NZ_CP019670:c3058527-3057961 [Burkholderia cenocepacia]
ATGCCCCATCCGCCGCTTCATCCATCCTCGCTCGGCCCGCAACTCAAGCGCTGGCGCGCGCTGCACCGCGTGAAGCAAAG
CCATGCAGCCGAACTGTTCGGCGTCGCGCAATCGACGATCTCCCGCTGGGAAGCCGGCCTTCAGCAGATGTCGCCCGCCG
AGCGCGCGACGGCTGAACGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGACCACGCACTCGCGCGGCTGATCGCCGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTGGCCAGTTCCCCAGCACGCGCGGCCGAGTTCTC
GCAACCGCTTTCGACGTTGCTCGGCACGTCGCTGTGGCGCTACGCGACACCGGAAATCGTGCGCATGGAAGCCGCGCTCG
ACGCGCTCGGCTGGCACGACCGCGCGGGGCCGCCGAGCGTCGAGTTCGACACCGGCGCGAATGCGTCGCGCGTCGTGCCG
ATTCGCGGCAGCCGATGCCGGTGGACACGGATGACGCTGTCGGACGGCTCGGCCGTGCGGCTCGTGGAAACGCTCGACGC
ACACTGA