Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 7392261..7394032 Replicon chromosome
Accession NZ_CP019668
Organism Burkholderia cenocepacia strain VC7848

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag A8E88_RS34675 Protein ID WP_077179428.1
Coordinates 7392261..7393178 (+) Length 306 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1K294
Locus tag A8E88_RS34680 Protein ID WP_011547426.1
Coordinates 7393175..7394032 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8E88_RS34645 7387642..7388721 - 1080 WP_011547420.1 porin -
A8E88_RS34650 7389156..7389473 + 318 WP_006478721.1 non-heme iron oxygenase ferredoxin subunit -
A8E88_RS34655 7389475..7389786 + 312 WP_011547421.1 hypothetical protein -
A8E88_RS34660 7389847..7390917 + 1071 WP_011547422.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
A8E88_RS34665 7390910..7391680 + 771 WP_011547423.1 SDR family oxidoreductase -
A8E88_RS34670 7391715..7392242 + 528 WP_011547424.1 cupin domain-containing protein -
A8E88_RS34675 7392261..7393178 + 918 WP_077179428.1 alpha/beta hydrolase Toxin
A8E88_RS34680 7393175..7394032 + 858 WP_011547426.1 IclR family transcriptional regulator Antitoxin
A8E88_RS34685 7394029..7394826 + 798 WP_006478728.1 SDR family oxidoreductase -
A8E88_RS34690 7394819..7396486 + 1668 WP_069231322.1 thiamine pyrophosphate-binding protein -
A8E88_RS34695 7396479..7397306 + 828 WP_011547429.1 aspartate dehydrogenase -
A8E88_RS34700 7397379..7398869 + 1491 WP_077179429.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(58-286)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 31306.63 Da        Isoelectric Point: 7.7111

>T73143 WP_077179428.1 NZ_CP019668:7392261-7393178 [Burkholderia cenocepacia]
MSVIDKRERERDRTAAFAALLGQFPEQRCAAGAAGAIGYREAGAGEAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGA
SRRVLAWDAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLVRVMPARIAGLLLISPAGGYG
SAPAETRESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEEAKAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRG
RTAVAVGANDAITPPAACERIAAAAYVGLQVIPQAGHAGYVEAPAVYSALIDTFCRQCDPQRGPA

Download         Length: 918 bp

>T73143 NZ_CP019668:7392261-7393178 [Burkholderia cenocepacia]
ATGAGTGTCATCGACAAACGCGAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCA
GCGTTGCGCGGCCGGCGCGGCGGGCGCGATCGGCTACCGTGAGGCGGGTGCAGGCGAGGCCGGCGCGCAGCATGCGGGCC
GTGCGCTGCCCGTCGTGCTGCTGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTCCGCCAGCTCGACACGCTGGGTGCA
TCGCGGCGCGTACTCGCGTGGGATGCGCCCGGTTACGGCGTGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGA
TTACGCGGCATCGCTGAACGCGTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGA
TCATCGCGGGCGGCCTCGTCCGCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGATTTCGCCCGCGGGCGGCTACGGC
AGCGCACCGGCCGAGACCCGCGAATCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGCCCGGCCGGGCTCGC
CGAGCAGCGCAGCGGCAACATGCTGTCCGGTTTCGCGAACGAGGAGGCAAAGGCATGGGTGCGCTGGAACATGGCGCGCA
TCGTGCCGGCCGGCTACGCGCAGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGGCCGATCTCGCCGGCTTTCGCGGC
CGCACGGCCGTGGCCGTCGGCGCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGTACGT
CGGGCTGCAGGTGATTCCGCAGGCGGGGCATGCCGGCTACGTGGAAGCGCCGGCCGTTTATTCCGCGCTGATCGACACGT
TCTGTCGTCAGTGCGACCCACAGCGGGGGCCGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31315.76 Da        Isoelectric Point: 6.5054

>AT73143 WP_011547426.1 NZ_CP019668:7393175-7394032 [Burkholderia cenocepacia]
MSEPLQQNESDNAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGALNRMTSATPETVDALYDVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT73143 NZ_CP019668:7393175-7394032 [Burkholderia cenocepacia]
ATGAGCGAACCGCTGCAACAAAACGAATCCGACAACGCGAAGGCCGAAGCCAGCTACGTCGTGCCGGGCCTCGAACGCGG
GCTGCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAACTGTCGAAACGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGTTTTCTCGAACGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGA
GAGCCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATTCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACCCGGCTGCCCGCGCACGCGACGACGCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAACTGCACGCGCTGTATCCGGAAGGCGCGCTGAACCGGATGACGAGCGCGAC
GCCGGAGACGGTTGACGCGCTGTACGACGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGGATCTCGGTCGTCACGGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGTCCGGAGATCGACGCGGCGCTGATCGCGGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAATTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTCTCAAAGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B1K294

References