Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 7295793..7296448 Replicon chromosome
Accession NZ_CP019668
Organism Burkholderia cenocepacia strain VC7848

Toxin (Protein)


Gene name vapC Uniprot ID A0A7G6V5T4
Locus tag A8E88_RS34165 Protein ID WP_006480895.1
Coordinates 7296029..7296448 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7G6V5T5
Locus tag A8E88_RS34160 Protein ID WP_034175232.1
Coordinates 7295793..7296032 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8E88_RS34140 7291466..7291702 - 237 WP_077178794.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
A8E88_RS34145 7291788..7292471 - 684 WP_074806203.1 Fe2+-dependent dioxygenase -
A8E88_RS34150 7292468..7293223 - 756 WP_077178795.1 sel1 repeat family protein -
A8E88_RS34155 7293227..7295470 - 2244 WP_077178796.1 TonB-dependent siderophore receptor -
A8E88_RS34160 7295793..7296032 + 240 WP_034175232.1 Arc family DNA-binding protein Antitoxin
A8E88_RS34165 7296029..7296448 + 420 WP_006480895.1 type II toxin-antitoxin system VapC family toxin Toxin
A8E88_RS34170 7296593..7297888 - 1296 WP_011547337.1 aspartate carbamoyltransferase -
A8E88_RS34175 7298123..7298257 + 135 WP_006485835.1 entericidin A/B family lipoprotein -
A8E88_RS34180 7298351..7298899 - 549 WP_077178797.1 permease -
A8E88_RS34185 7299102..7300034 - 933 WP_027812829.1 DMT family transporter -
A8E88_RS34190 7300216..7301010 - 795 WP_027812828.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-41)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14962.15 Da        Isoelectric Point: 4.9008

>T73142 WP_006480895.1 NZ_CP019668:7296029-7296448 [Burkholderia cenocepacia]
MILVDTNVISEPLRREPNAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEQRVVPLFRGRVLPFDD
AASKAYASLRAKARGTGNAMASADGFIAATAAANGLIVATRDVAPFEAAGLRVIDPWAA

Download         Length: 420 bp

>T73142 NZ_CP019668:7296029-7296448 [Burkholderia cenocepacia]
ATGATCCTCGTCGATACCAACGTCATTTCCGAGCCGCTGCGGCGCGAGCCGAACGCGGCCGTGATCGAATGGCTCGACGC
GCAGAACGTCGAGACGCTGTTTCTTGCCGCGATCAGTCTGGCGGAAATGCGCTTCGGCGTGGCGGCGTTGCCGGAGGGCC
GTCGGCGGGACTGGCTCGAGCAAAGTATCGAGCAGCGCGTCGTGCCGTTGTTTCGCGGCCGGGTCCTGCCGTTCGATGAT
GCGGCCAGCAAGGCGTACGCGAGCCTGCGCGCCAAGGCGCGTGGTACGGGCAACGCGATGGCGTCTGCCGACGGCTTCAT
TGCCGCAACCGCCGCGGCGAACGGGCTGATCGTGGCCACGCGCGACGTCGCGCCGTTCGAGGCAGCAGGCCTGCGTGTGA
TCGACCCTTGGGCCGCCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8747.88 Da        Isoelectric Point: 6.4685

>AT73142 WP_034175232.1 NZ_CP019668:7295793-7296032 [Burkholderia cenocepacia]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRDILEQAVRPGGRPRLGTLLAEIGREAGGIDFEVRRDASSTDPMSFE

Download         Length: 240 bp

>AT73142 NZ_CP019668:7295793-7296032 [Burkholderia cenocepacia]
ATGCCCGTGATCACCGTTCGAAATTTGCCCGACGAAGTGCATCGCGCGCTTCGAATCCGGGCCGCGCAACATGGCCGCAG
TACCGAAGCCGAGGTGCGAGACATTCTCGAGCAAGCCGTTCGGCCCGGCGGCCGACCCAGGCTCGGGACGCTGCTGGCTG
AAATCGGCCGGGAAGCGGGCGGCATCGATTTCGAAGTTCGGCGCGACGCATCGTCAACCGATCCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G6V5T4

Antitoxin

Source ID Structure
AlphaFold DB A0A7G6V5T5

References