Detailed information of TA system TA073141

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 7211387..7211910
• Replicon: chromosome
• Accession: NZ_CP019668
• Organism: Burkholderia cenocepacia strain VC7848

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: A8E88_RS33810
• Protein ID: WP_077180080.1
• Coordinates: 7211387..7211653 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1K8I6
• Locus tag: A8E88_RS33815
• Protein ID: WP_011547275.1
• Coordinates: 7211650..7211910 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8E88_RS33785	7206678..7207916	-	1239	WP_006480829.1	diaminopimelate decarboxylase	-
A8E88_RS33790	7208024..7208938	+	915	WP_027811415.1	LysR family transcriptional regulator	-
A8E88_RS33795	7208999..7209598	+	600	WP_012339671.1	GNAT family N-acetyltransferase	-
A8E88_RS33800	7209720..7210298	-	579	WP_077180082.1	DUF4142 domain-containing protein	-
A8E88_RS33805	7210714..7211337	-	624	WP_077180081.1	HAD hydrolase-like protein	-
A8E88_RS33810	7211387..7211653	-	267	WP_077180080.1	Txe/YoeB family addiction module toxin	Toxin
A8E88_RS33815	7211650..7211910	-	261	WP_011547275.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
A8E88_RS33820	7212115..7212558	+	444	WP_077195082.1	GNAT family N-acetyltransferase	-
A8E88_RS33825	7212616..7212834	+	219	WP_006480837.1	DUF1653 domain-containing protein	-
A8E88_RS33830	7212857..7213315	-	459	WP_077180079.1	ATP synthase F1 subunit epsilon	-
A8E88_RS33835	7213326..7214195	-	870	WP_077180078.1	ATP synthase F1 subunit gamma	-
A8E88_RS33840	7214344..7215312	+	969	WP_077180077.1	phosphate acetyltransferase	-
A8E88_RS33845	7215323..7216543	+	1221	WP_077180076.1	acetate/propionate family kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10557.87 Da
• Isoelectric Point: 6.9774

>T73141 WP_077180080.1 NZ_CP019668:c7211653-7211387 [Burkholderia cenocepacia]
MSVRRVLFTSDAWDDYVYWQGQDRKTLKRINQLIRETQRTPFEGIGKPEPLKANLSGFWSRRIDDTDRLVYEADDLQLSI
VSCRYHYE

Nucleotide

• Length: 267 bp

>T73141 NZ_CP019668:c7211653-7211387 [Burkholderia cenocepacia]
ATGAGCGTACGTCGCGTGCTCTTTACTTCCGACGCATGGGATGACTATGTCTACTGGCAAGGACAGGATCGCAAGACGCT
CAAGCGCATCAACCAGCTCATTCGCGAAACCCAGCGCACGCCGTTCGAAGGCATCGGCAAGCCGGAGCCGTTGAAAGCCA
ATCTCTCCGGCTTCTGGTCGCGCCGTATCGACGATACGGACCGCCTGGTCTACGAGGCTGACGACCTTCAACTCAGCATC
GTGTCCTGCCGCTACCATTACGAGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9745.00 Da
• Isoelectric Point: 6.0717

>AT73141 WP_011547275.1 NZ_CP019668:c7211910-7211650 [Burkholderia cenocepacia]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQDYYDSLMETVHLLRSPANVAHLERSIAQLRKGKAKEHK
LAEDDE

Nucleotide

• Length: 261 bp

>AT73141 NZ_CP019668:c7211910-7211650 [Burkholderia cenocepacia]
ATGCGCACGATTCATTTTTCCGATGCCCGCGGCAATCTGAAGACCGTCATCGACCAGGTCGTCGACGATGCCGACGTGAC
GCTCATTACGCGCCGCGATGCACCGAACGCCGTCATCATGTCGCAGGACTATTACGACAGCCTGATGGAGACGGTTCACC
TGCTGCGCTCGCCAGCCAACGTCGCTCATCTCGAGCGCTCGATCGCGCAACTGCGCAAGGGCAAAGCGAAAGAACACAAG
CTCGCCGAGGATGATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1J9NJ62