Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 6338039..6338676 Replicon chromosome
Accession NZ_CP019668
Organism Burkholderia cenocepacia strain VC7848

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A8E88_RS29715 Protein ID WP_077180124.1
Coordinates 6338275..6338676 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag A8E88_RS29710 Protein ID WP_077180155.1
Coordinates 6338039..6338275 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8E88_RS29690 6334101..6335198 - 1098 WP_077180128.1 ADP-heptose--LPS heptosyltransferase -
A8E88_RS29695 6335195..6336898 - 1704 WP_077180127.1 thiamine pyrophosphate-binding protein -
A8E88_RS29700 6337179..6337640 + 462 WP_077180126.1 hypothetical protein -
A8E88_RS29705 6337637..6337921 + 285 WP_077180125.1 type II toxin-antitoxin system RelE/ParE family toxin -
A8E88_RS29710 6338039..6338275 + 237 WP_077180155.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
A8E88_RS29715 6338275..6338676 + 402 WP_077180124.1 type II toxin-antitoxin system VapC family toxin Toxin
A8E88_RS29720 6338744..6340132 - 1389 WP_059503223.1 L-serine ammonia-lyase -
A8E88_RS29725 6340163..6341305 - 1143 WP_027807898.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14893.04 Da        Isoelectric Point: 5.7369

>T73139 WP_077180124.1 NZ_CP019668:6338275-6338676 [Burkholderia cenocepacia]
MPRFMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTACASPARERRNLAALIEDIPVAPFGAAAAQA
YGPVRDATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGVRLENWLND

Download         Length: 402 bp

>T73139 NZ_CP019668:6338275-6338676 [Burkholderia cenocepacia]
ATGCCGCGCTTCATGCTCGACACCAACATGTGCATCTACCTGATGAAAAATCAGCCGGAGCAGGTCGCGAGACGGTTTGC
GCAGTGCTACACGGGCGACGTCGTCATGTCGGCGATCACCTATGCTGAGCTCGAATACGGCGTGACCGCATGTGCGAGCC
CTGCCCGGGAGCGCCGCAATCTCGCTGCGTTGATCGAGGATATTCCCGTCGCGCCTTTCGGCGCCGCGGCTGCGCAAGCA
TATGGCCCGGTCCGCGACGCCACCCGCGAGCGGAAGAAGGATCACCTCGACAAACTGATCGCCGCGCATGCGGTGTCGCT
CGATGTCGTCCTGGTGACCAACAACGAGCGGGATTTCGTCAGCTATCCGGGGGTGCGACTGGAGAACTGGCTGAACGACT
AG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9026.20 Da        Isoelectric Point: 6.4712

>AT73139 WP_077180155.1 NZ_CP019668:6338039-6338275 [Burkholderia cenocepacia]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPMRRPLTQVLAKFAKFGPDFMTEGRGDHEQAEREGL

Download         Length: 237 bp

>AT73139 NZ_CP019668:6338039-6338275 [Burkholderia cenocepacia]
ATGCATACCACGAGGGTATTTAGGAACGGCAACTCGCAGGCTGTGCGTATTCCTGCGGACCTTGCCTATGAGCGCAGCGA
TATCGAACTGGAAATCGAACGCGTCGGTGACGAAATCCGCATTCGGCCGATGCGGCGGCCTTTGACTCAGGTACTGGCGA
AGTTCGCGAAATTCGGGCCGGACTTCATGACAGAAGGGCGTGGCGACCACGAGCAGGCCGAACGCGAGGGTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References