Detailed information of TA system TA073135

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 2102751..2103316
• Replicon: chromosome
• Accession: NZ_CP019668
• Organism: Burkholderia cenocepacia strain VC7848

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: A8E88_RS09765
• Protein ID: WP_011546880.1
• Coordinates: 2102751..2103122 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B1FGI9
• Locus tag: A8E88_RS09770
• Protein ID: WP_006752328.1
• Coordinates: 2103119..2103316 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8E88_RS09750	2098612..2099337	+	726	WP_011546877.1	site-2 protease family protein	-
A8E88_RS09755	2099404..2100759	-	1356	WP_166488170.1	MFS transporter	-
A8E88_RS09760	2101046..2102623	+	1578	WP_011546879.1	aldehyde dehydrogenase (NADP(+))	-
A8E88_RS09765	2102751..2103122	-	372	WP_011546880.1	PIN domain-containing protein	Toxin
A8E88_RS09770	2103119..2103316	-	198	WP_006752328.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
A8E88_RS09775	2103502..2104056	+	555	WP_006480480.1	hypothetical protein	-
A8E88_RS09780	2104171..2105085	-	915	WP_011546881.1	5-dehydro-4-deoxyglucarate dehydratase	-
A8E88_RS09785	2105315..2106868	+	1554	WP_011546882.1	galactarate dehydratase	-
A8E88_RS09790	2107087..2107479	+	393	WP_077177808.1	nuclear transport factor 2 family protein	-
A8E88_RS09795	2107558..2108013	+	456	WP_006480483.1	RbsD/FucU family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-46)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13559.67 Da
• Isoelectric Point: 6.2156

>T73135 WP_011546880.1 NZ_CP019668:c2103122-2102751 [Burkholderia cenocepacia]
MILVDTSVWIDHLRAGDATLTALLEAERVLIHPFIVGELALGSMRHRETVLDALRDLPAATLATDDEVQRMIDAVPLHGL
GIGYVDAHLLASARLTSDSRLWTRDRRLLAAAERLQLVARPAH

Nucleotide

• Length: 372 bp

>T73135 NZ_CP019668:c2103122-2102751 [Burkholderia cenocepacia]
ATGATCCTTGTCGACACATCCGTCTGGATCGATCACTTGCGAGCCGGCGACGCGACGCTCACCGCCTTGCTGGAAGCGGA
GCGAGTATTGATCCATCCGTTCATCGTCGGCGAGCTTGCGCTCGGCAGCATGCGCCATCGCGAGACCGTGCTGGATGCGC
TGCGCGACCTTCCAGCTGCAACCCTTGCCACCGACGACGAAGTCCAGCGCATGATCGATGCCGTACCGCTTCACGGGCTG
GGCATCGGGTACGTCGATGCCCACCTGCTTGCGTCGGCCAGACTGACCAGCGACAGCAGGCTATGGACGCGCGACCGGCG
CCTGCTGGCGGCAGCGGAGCGCCTGCAACTCGTCGCCCGCCCCGCTCACTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7054.10 Da
• Isoelectric Point: 10.6826

>AT73135 WP_006752328.1 NZ_CP019668:c2103316-2103119 [Burkholderia cenocepacia]
MRTTLSLDDALLAKAQQLTGVTEKSALVREALRALIARESARRLARLGGTEPDLESVPRRPSEPA

Nucleotide

• Length: 198 bp

>AT73135 NZ_CP019668:c2103316-2103119 [Burkholderia cenocepacia]
ATGCGCACCACCTTGTCCCTCGACGACGCACTGCTCGCCAAAGCGCAGCAATTGACCGGCGTCACCGAAAAATCGGCGCT
CGTGAGGGAAGCGCTGCGCGCATTGATCGCCCGCGAAAGTGCGCGACGACTCGCCCGCCTCGGCGGCACCGAGCCTGATC
TTGAATCGGTCCCACGCCGCCCGTCGGAGCCCGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A2S9KMB8