Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbE-relB/ParE-YafN
Location 1921916..1922430 Replicon chromosome
Accession NZ_CP019668
Organism Burkholderia cenocepacia strain VC7848

Toxin (Protein)


Gene name stbE Uniprot ID -
Locus tag A8E88_RS08905 Protein ID WP_077178611.1
Coordinates 1922212..1922430 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag A8E88_RS08900 Protein ID WP_077178610.1
Coordinates 1921916..1922164 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8E88_RS08880 1917627..1918847 - 1221 WP_023477579.1 CoA transferase -
A8E88_RS08885 1918928..1919710 - 783 WP_077178608.1 crotonase/enoyl-CoA hydratase family protein -
A8E88_RS08890 1919845..1920609 + 765 WP_023477581.1 helix-turn-helix domain-containing protein -
A8E88_RS08895 1920735..1921787 + 1053 WP_077178609.1 CoA transferase -
A8E88_RS08900 1921916..1922164 + 249 WP_077178610.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
A8E88_RS08905 1922212..1922430 + 219 WP_077178611.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A8E88_RS08910 1922473..1922916 - 444 WP_006480333.1 PaaI family thioesterase -
A8E88_RS08915 1923195..1924814 + 1620 WP_077178612.1 Tar ligand binding domain-containing protein -
A8E88_RS08920 1924787..1925896 - 1110 WP_077178613.1 AGE family epimerase/isomerase -
A8E88_RS08925 1926012..1926710 + 699 WP_011548926.1 MgtC/SapB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-63)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8407.88 Da        Isoelectric Point: 11.0031

>T73134 WP_077178611.1 NZ_CP019668:1922212-1922430 [Burkholderia cenocepacia]
VRDQFKARLAERLEHPRIPSAKLHGHPDRYKIKLRGVGYRLVYEVRDAEVIVLVVAVGRRERDAVYLAAMKR

Download         Length: 219 bp

>T73134 NZ_CP019668:1922212-1922430 [Burkholderia cenocepacia]
GTGCGCGATCAATTCAAGGCCAGGCTCGCCGAGCGGCTCGAGCATCCTCGTATCCCGTCAGCCAAATTGCATGGCCACCC
GGATCGCTACAAGATCAAGCTGCGCGGTGTCGGTTATCGCCTCGTCTACGAAGTGCGCGACGCGGAAGTCATCGTGCTGG
TGGTCGCGGTGGGCCGCCGCGAGCGTGATGCGGTCTATCTGGCTGCGATGAAACGCTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9056.29 Da        Isoelectric Point: 4.7318

>AT73134 WP_077178610.1 NZ_CP019668:1921916-1922164 [Burkholderia cenocepacia]
MPHTILASVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDTDDNAMADSRAREKIVKVNWN
DL

Download         Length: 249 bp

>AT73134 NZ_CP019668:1921916-1922164 [Burkholderia cenocepacia]
ATGCCTCACACCATTCTGGCTAGCGTGACGGCTAGCGTCTCGGAGCTGAAGCGGAATCCGATGGGAACCGTTGCCGCGGG
CGAGGGTTTTCCGGTCGCCATCCTGAATCACAACGAACCCGCGTTCTACTGCATTCCAGCGAAGACGTGGGAGGCGATGG
TCGAACGCCTGGAAGACACCGACGACAATGCGATGGCCGATTCGCGCGCCAGGGAGAAGATCGTCAAGGTCAATTGGAAT
GACCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References