Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 616632..617278 Replicon chromosome
Accession NZ_CP019668
Organism Burkholderia cenocepacia strain VC7848

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A8E88_RS02765 Protein ID WP_077179693.1
Coordinates 616632..617039 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag A8E88_RS02770 Protein ID WP_069230948.1
Coordinates 617036..617278 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8E88_RS02750 612514..613095 - 582 WP_077179691.1 hypothetical protein -
A8E88_RS02755 613092..613820 - 729 WP_077179728.1 chemotaxis protein -
A8E88_RS02760 613843..616230 - 2388 WP_077179692.1 MCP four helix bundle domain-containing protein -
A8E88_RS02765 616632..617039 - 408 WP_077179693.1 type II toxin-antitoxin system VapC family toxin Toxin
A8E88_RS02770 617036..617278 - 243 WP_069230948.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
A8E88_RS02775 617536..618219 + 684 WP_023476531.1 serine esterase -
A8E88_RS02780 618289..619794 - 1506 WP_077179694.1 amino acid permease -
A8E88_RS02785 619871..621277 - 1407 WP_027808950.1 aspartate ammonia-lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14861.92 Da        Isoelectric Point: 6.1304

>T73132 WP_077179693.1 NZ_CP019668:c617039-616632 [Burkholderia cenocepacia]
MKFLLDTNAVIAILKGEPAILARLHAWHPADFGVPAIVAHELYYGAYKSQRAAANVARVDALQFEVVSFDTEDAQHAGEI
RAHLIAAGTPIGPYDALIAGQARARHLVLVTHNVREFERVPRLQFEDWLAEPSEG

Download         Length: 408 bp

>T73132 NZ_CP019668:c617039-616632 [Burkholderia cenocepacia]
ATGAAGTTCCTGCTGGATACCAACGCGGTGATCGCCATTCTCAAAGGCGAGCCGGCGATACTGGCCCGTTTGCATGCCTG
GCACCCGGCCGATTTCGGGGTCCCGGCGATCGTCGCGCACGAGCTCTATTACGGCGCGTACAAGAGCCAGCGAGCGGCTG
CGAACGTCGCGCGTGTCGACGCGCTGCAGTTCGAGGTCGTATCGTTCGACACCGAGGATGCACAGCATGCGGGTGAAATT
CGTGCGCACCTGATCGCGGCCGGCACGCCGATCGGTCCATACGATGCATTGATCGCAGGGCAGGCGCGTGCGCGGCACCT
GGTGCTGGTCACGCACAACGTCCGCGAATTCGAGCGCGTTCCGCGGCTGCAATTCGAAGACTGGCTCGCCGAGCCGAGCG
AAGGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8834.99 Da        Isoelectric Point: 5.0197

>AT73132 WP_069230948.1 NZ_CP019668:c617278-617036 [Burkholderia cenocepacia]
MDTAKLFKHGGSQAVRLPKDFRFDTAEVRIRRHGAAVILEPMPQDWAWLAPLIGPVDADFEAAATTQPSGQERSGLDVFE

Download         Length: 243 bp

>AT73132 NZ_CP019668:c617278-617036 [Burkholderia cenocepacia]
ATGGATACTGCAAAGCTCTTCAAGCATGGCGGCTCGCAGGCTGTCCGGCTACCGAAGGATTTCCGCTTCGATACGGCCGA
GGTCCGCATCCGCCGCCACGGGGCGGCCGTCATTCTCGAGCCGATGCCGCAAGACTGGGCTTGGCTGGCACCGCTGATCG
GTCCGGTGGACGCCGATTTCGAGGCTGCCGCGACCACGCAGCCGTCCGGTCAGGAGCGCTCGGGTCTGGACGTGTTCGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References