Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 244390..246131 Replicon chromosome
Accession NZ_CP019668
Organism Burkholderia cenocepacia strain VC7848

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag A8E88_RS01135 Protein ID WP_077179242.1
Coordinates 244791..246131 (+) Length 447 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag A8E88_RS01130 Protein ID WP_077179275.1
Coordinates 244390..244788 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8E88_RS01105 239652..240671 - 1020 WP_011547696.1 DNA-binding protein -
A8E88_RS01115 241343..242263 - 921 WP_077179239.1 alpha/beta hydrolase -
A8E88_RS01120 242270..242866 - 597 WP_077179240.1 hypothetical protein -
A8E88_RS01125 243273..243938 + 666 WP_077179241.1 cation diffusion facilitator family transporter -
A8E88_RS01130 244390..244788 + 399 WP_077179275.1 helix-turn-helix domain-containing protein Antitoxin
A8E88_RS01135 244791..246131 + 1341 WP_077179242.1 type II toxin-antitoxin system HipA family toxin Toxin
A8E88_RS01140 246290..247417 - 1128 WP_011547703.1 VOC family protein -
A8E88_RS01150 247775..249082 + 1308 WP_077179244.1 shikimate transporter -
A8E88_RS01155 249304..250605 + 1302 WP_023477875.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-67)


Sequences

Toxin        


Download         Length: 447 a.a.        Molecular weight: 48971.81 Da        Isoelectric Point: 7.1859

>T73131 WP_077179242.1 NZ_CP019668:244791-246131 [Burkholderia cenocepacia]
MVARARSDRLDLWMNGIPVGYWEIRRGVERLVYLPDWLDDPQGRPLSLSLPFTPGNQPHQGAIVADYFDNLLPDSEPIRR
RIAQRYRLRSTAPFELLASIGRDCVGAIQMLPPDETPVDLEAIEGAPLDDAAVADVLRHATATPLPGSGEPDGDLHLSIA
GAQEKTALLRQRNRWLRPSGSTPTTHIFKLPLGRVGNMQADMRTSVENEWLCSKLVAAYGLSVAPCEIGRFDDQKALIVE
RFDRRPSRDGSWILRLPQEDMCQATGTPSGAKYETDGGPGIETIMGILANSADASRDRMNFFVAQLVFWVLAAIDGHAKN
FSIAHLPGNAYRSTPLYDVLSAHPIIGTRRNQIPPRRARLAMAVCGKNRHYVIGEIQPRHWIVQGRRVGLTEDNVRAAMA
AVAARTEPAIAEAAAQIPPDFPADVADAIFAGMRRQSRNLAAADPA

Download         Length: 1341 bp

>T73131 NZ_CP019668:244791-246131 [Burkholderia cenocepacia]
ATGGTCGCACGCGCCCGCAGCGACCGGCTCGACCTGTGGATGAACGGCATTCCTGTCGGCTACTGGGAAATCCGGCGCGG
GGTCGAGCGTCTCGTCTACCTGCCGGACTGGCTCGATGATCCCCAGGGCCGGCCACTGTCATTGTCGCTGCCCTTCACGC
CCGGCAACCAGCCGCACCAGGGTGCGATCGTGGCCGACTACTTCGACAACCTGCTGCCGGACAGCGAGCCGATCCGCCGC
CGCATCGCGCAGCGTTACCGGCTCCGATCGACAGCGCCGTTCGAATTGCTCGCGTCGATCGGCCGCGATTGCGTCGGCGC
GATCCAAATGCTGCCGCCCGACGAGACCCCGGTCGATCTCGAGGCAATCGAAGGCGCGCCGCTCGACGACGCAGCCGTTG
CCGATGTGCTGCGCCACGCGACCGCCACGCCACTGCCCGGCAGCGGAGAACCGGACGGCGACCTGCACCTGTCGATTGCC
GGCGCGCAGGAAAAGACCGCGCTGCTGCGTCAGCGTAACCGCTGGCTGCGGCCGTCGGGCAGCACGCCGACGACCCACAT
CTTCAAGCTGCCGCTCGGGCGCGTCGGCAACATGCAGGCCGACATGCGCACGTCCGTCGAAAACGAATGGTTGTGCTCGA
AGCTCGTCGCCGCGTACGGCCTGTCGGTCGCGCCGTGCGAAATCGGCCGGTTCGACGATCAGAAGGCACTCATCGTCGAG
CGCTTCGACCGTCGCCCGTCGCGCGACGGCTCGTGGATCCTGCGGCTGCCGCAGGAGGACATGTGTCAGGCGACCGGCAC
GCCGTCGGGGGCGAAATACGAAACGGACGGCGGCCCCGGCATCGAGACGATCATGGGCATCCTCGCGAATTCGGCCGACG
CTTCGCGCGACCGGATGAATTTCTTTGTCGCACAGCTTGTATTCTGGGTGTTGGCGGCGATCGACGGCCACGCGAAGAAC
TTCAGCATCGCGCACCTGCCCGGGAATGCGTATCGCAGCACGCCGCTGTACGACGTGTTGTCCGCGCATCCGATCATCGG
TACGCGCCGCAACCAGATCCCGCCGCGCCGCGCCCGCCTGGCGATGGCCGTCTGCGGGAAGAACCGGCACTACGTGATCG
GTGAAATCCAGCCGCGCCACTGGATCGTACAGGGCCGTCGTGTCGGCCTGACCGAAGACAATGTGCGGGCCGCGATGGCG
GCCGTCGCAGCACGGACGGAGCCCGCGATTGCCGAAGCCGCCGCGCAGATCCCGCCGGACTTTCCCGCGGACGTGGCAGA
CGCGATCTTCGCGGGCATGCGTCGGCAAAGCCGCAACCTCGCGGCGGCCGATCCGGCGTGA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14203.29 Da        Isoelectric Point: 11.9664

>AT73131 WP_077179275.1 NZ_CP019668:244390-244788 [Burkholderia cenocepacia]
MAFPVQTLTQLRPILVGFRKSAGLTQAQLAARLGITQQSYAQLEANPSAVSIERLFKVMNALGVRMTLSLDERDAPAEAA
DSASAAEPVARRKPVASKRGTTAAKTPTGTAARRRPTATTRTTPRVSKREDW

Download         Length: 399 bp

>AT73131 NZ_CP019668:244390-244788 [Burkholderia cenocepacia]
ATGGCCTTTCCTGTCCAGACCCTGACCCAGTTGCGTCCGATCCTCGTCGGCTTCCGCAAATCCGCGGGGCTCACGCAGGC
GCAACTGGCCGCTCGCCTCGGCATCACCCAGCAATCTTATGCTCAGCTCGAAGCCAACCCCTCGGCGGTCAGCATCGAGC
GGCTTTTCAAGGTGATGAACGCGCTTGGCGTTCGCATGACGCTCAGCCTCGACGAGCGGGATGCACCGGCGGAAGCGGCC
GATTCGGCTTCCGCCGCCGAACCGGTGGCGCGCCGCAAGCCGGTCGCGAGCAAGCGCGGCACCACGGCCGCCAAAACCCC
GACCGGCACCGCCGCGCGGAGGCGCCCGACAGCGACGACTCGGACCACGCCACGCGTCTCGAAGAGGGAGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References