Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3515588..3516183 Replicon chromosome
Accession NZ_CP019659
Organism Paenibacillus larvae subsp. larvae strain Eric_IV

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ERICIV_RS18215 Protein ID WP_077997555.1
Coordinates 3515890..3516183 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W2E434
Locus tag ERICIV_RS18210 Protein ID WP_036658190.1
Coordinates 3515588..3515857 (+) Length 90 a.a.

Genomic Context

ERICIV_RS18190ERICIV_RS18200ERICIV_RS18210ERICIV_RS18215ERICIV_RS18220ERICIV_RS18225ERICIV_RS18230ERICIV_RS18195ERICIV_RS18205
Location: 3510601..3511215 (615 bp)
Type: Others
Protein ID: WP_077996009.1
Location: 3513423..3514709 (1287 bp)
Type: Others
Protein ID: WP_077996011.1
Location: 3515588..3515857 (270 bp)
Type: Antitoxin
Protein ID: WP_036658190.1
Location: 3515890..3516183 (294 bp)
Type: Toxin
Protein ID: WP_077997555.1
Location: 3516435..3516725 (291 bp)
Type: Others
Protein ID: WP_023483432.1
Location: 3516722..3519232 (2511 bp)
Type: Others
Protein ID: WP_077996013.1
Location: 3519337..3519633 (297 bp)
Type: Others
Protein ID: WP_036658187.1
Location: 3511247..3513163 (1917 bp)
Type: Others
Protein ID: WP_077996010.1
Location: 3514937..3515269 (333 bp)
Type: Others
Protein ID: WP_077996012.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ERICIV_RS181903510601..3511215+615WP_077996009.1sigma-70 family RNA polymerase sigma factor-
ERICIV_RS181953511247..3513163-1917WP_077996010.1AAA family ATPase-
ERICIV_RS182003513423..3514709+1287WP_077996011.1MFS transporter-
ERICIV_RS182053514937..3515269-333WP_077996012.1hypothetical protein-
ERICIV_RS182103515588..3515857+270WP_036658190.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
ERICIV_RS182153515890..3516183+294WP_077997555.1type II toxin-antitoxin system PemK/MazF family toxinToxin
ERICIV_RS182203516435..3516725+291WP_023483432.1metalloregulator ArsR/SmtB family transcription factor-
ERICIV_RS182253516722..3519232+2511WP_077996013.1FAD-dependent oxidoreductase-
ERICIV_RS182303519337..3519633+297WP_036658187.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--3520736..35219591223


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-96)

Antitoxin

Antitoxin PemI-like

(11-89)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10996.75 Da        Isoelectric Point: 7.2775

>T73128 WP_077997555.1 NZ_CP019659:3515890-3516183 [Paenibacillus larvae subsp. larvae]
MDFNPQIGHEQAGRRPGLVVSPTSFNRVTGFIVVCPITRTVRNYPYEVPLPSDLMTEGVVLAHQVKSLDWKARKAEVREK
VPKEIIDDVLDLIHTFL

Download         Length: 294 bp

>T73128 NZ_CP019659:3515890-3516183 [Paenibacillus larvae subsp. larvae]
ATGGATTTTAACCCGCAGATTGGACATGAACAAGCCGGAAGAAGACCAGGCCTTGTTGTCTCTCCTACATCATTCAATAG
GGTAACAGGCTTTATAGTTGTATGCCCTATTACAAGAACCGTTAGGAATTATCCATATGAAGTTCCCCTCCCTTCCGATC
TTATGACCGAAGGTGTTGTTTTGGCTCATCAAGTAAAAAGCTTGGATTGGAAGGCAAGAAAGGCAGAAGTTCGGGAAAAA
GTACCAAAAGAAATTATTGACGATGTACTGGATTTAATTCACACTTTCCTATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10006.46 Da        Isoelectric Point: 5.7379

>AT73128 WP_036658190.1 NZ_CP019659:3515588-3515857 [Paenibacillus larvae subsp. larvae]
MGKDRERMSVMSTIVSKWGNSLAIRIPSNLAESLNIKEGSEVELSIMDSTLTIKPKKRKPTLEELLAKITDGNHHEEIDF
GKPEGNEVW

Download         Length: 270 bp

>AT73128 NZ_CP019659:3515588-3515857 [Paenibacillus larvae subsp. larvae]
ATGGGTAAAGACAGGGAAAGGATGAGTGTAATGAGCACAATTGTGAGCAAATGGGGAAACAGTCTCGCAATCCGCATTCC
AAGTAACCTGGCAGAAAGCCTAAACATAAAAGAGGGTTCTGAAGTTGAATTAAGCATCATGGATAGTACACTAACTATAA
AACCTAAAAAACGTAAGCCAACTCTCGAAGAATTACTGGCAAAAATAACAGACGGTAACCATCATGAGGAAATTGACTTT
GGAAAACCGGAGGGGAACGAGGTTTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2L1TQJ8

References