Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 23577..24142 Replicon plasmid unnamed2
Accession NZ_CP019657
Organism Paenibacillus larvae subsp. larvae strain Eric_III

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ERICIII_RS23870 Protein ID WP_077997739.1
Coordinates 23813..24142 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ERICIII_RS23865 Protein ID WP_077997741.1
Coordinates 23577..23816 (+) Length 80 a.a.

Genomic Context

ERICIII_RS25055ERICIII_RS23850ERICIII_RS23855ERICIII_RS23865ERICIII_RS23870ERICIII_RS23895ERICIII_RS23900ERICIII_RS23845ERICIII_RS23860ERICIII_RS25060ERICIII_RS23875ERICIII_RS23885ERICIII_RS23890
Location: 19604..19807 (204 bp)
Type: Others
Protein ID: WP_158672847.1
Location: 20362..21819 (1458 bp)
Type: Others
Protein ID: WP_077997736.1
Location: 21857..22531 (675 bp)
Type: Others
Protein ID: WP_077997737.1
Location: 23577..23816 (240 bp)
Type: Antitoxin
Protein ID: WP_077997741.1
Location: 23813..24142 (330 bp)
Type: Toxin
Protein ID: WP_077997739.1
Location: 26744..27427 (684 bp)
Type: Others
Protein ID: WP_077996502.1
Location: 27391..28317 (927 bp)
Type: Others
Protein ID: Protein_32
Location: 19921..20181 (261 bp)
Type: Others
Protein ID: Protein_21
Location: 22692..22943 (252 bp)
Type: Others
Protein ID: WP_077997738.1
Location: 22951..23097 (147 bp)
Type: Others
Protein ID: WP_155121122.1
Location: 24387..25025 (639 bp)
Type: Others
Protein ID: WP_077997682.1
Location: 25793..26071 (279 bp)
Type: Others
Protein ID: WP_077997683.1
Location: 26181..26387 (207 bp)
Type: Others
Protein ID: WP_077997684.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ERICIII_RS2505519604..19807+204WP_158672847.1winged helix-turn-helix transcriptional regulator-
ERICIII_RS2384519921..20181-261Protein_21transposase-
ERICIII_RS2385020362..21819+1458WP_077997736.1SIR2 family protein-
ERICIII_RS2385521857..22531+675WP_077997737.1TIR domain-containing protein-
ERICIII_RS2386022692..22943-252WP_077997738.1hypothetical protein-
ERICIII_RS2506022951..23097-147WP_155121122.1hypothetical protein-
ERICIII_RS2386523577..23816+240WP_077997741.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
ERICIII_RS2387023813..24142+330WP_077997739.1type II toxin-antitoxin system PemK/MazF family toxinToxin
ERICIII_RS2387524387..25025-639WP_077997682.1hemolysin III family protein-
ERICIII_RS2388525793..26071-279WP_077997683.1HU family DNA-binding protein-
ERICIII_RS2389026181..26387-207WP_077997684.1cold-shock protein-
ERICIII_RS2389526744..27427+684WP_077996502.1helix-turn-helix domain-containing protein-
ERICIII_RS2390027391..28317+927Protein_32IS3 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..6086860868


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-108)

Antitoxin

Antitoxin PemI-like

(1-79)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12407.45 Da        Isoelectric Point: 7.3587

>T73125 WP_077997739.1 NZ_CP019657:23813-24142 [Paenibacillus larvae subsp. larvae]
VTVVPDRGDIVYMDFNPQSGHEQAGWRPALVLSPKLFNATTNLAVVCPITSRIKGYLFEVHLPDAMMTKGVILVHQLKSA
DWRSRRLEIREKAPQEIIDEVIEKIHTFL

Download         Length: 330 bp

>T73125 NZ_CP019657:23813-24142 [Paenibacillus larvae subsp. larvae]
GTGACAGTTGTTCCAGATCGCGGTGATATCGTTTATATGGACTTTAATCCACAGAGCGGACATGAACAAGCCGGGTGGCG
ACCAGCCCTTGTACTGTCACCAAAATTATTTAATGCTACAACGAATCTTGCTGTAGTCTGCCCTATCACTTCTAGAATTA
AAGGCTACTTATTTGAAGTTCATCTTCCAGACGCAATGATGACAAAAGGTGTTATACTTGTGCACCAATTGAAAAGCGCC
GATTGGAGATCGCGGAGATTAGAAATTAGGGAGAAAGCACCACAAGAAATTATTGACGAAGTGATTGAAAAGATTCATAC
TTTCCTATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8957.25 Da        Isoelectric Point: 5.6987

>AT73125 WP_077997741.1 NZ_CP019657:23577-23816 [Paenibacillus larvae subsp. larvae]
MSTLVSKWGNSLALRIPRHFAESLNLNEGSEVELKLTEDCLSVKPKKRKYTLEELCASIKDGNQHDLIDFGKPVGEEIW

Download         Length: 240 bp

>AT73125 NZ_CP019657:23577-23816 [Paenibacillus larvae subsp. larvae]
ATGAGCACGCTTGTAAGCAAATGGGGAAATAGTCTGGCACTTCGTATTCCCAGACATTTTGCTGAAAGCTTAAATCTTAA
TGAAGGCTCTGAAGTTGAATTAAAGCTAACAGAAGACTGCTTGAGTGTCAAGCCGAAGAAGAGAAAGTATACCCTTGAGG
AACTTTGTGCTTCTATTAAAGACGGTAATCAGCATGACCTTATTGATTTCGGTAAACCTGTTGGGGAGGAAATTTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References