Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 87164..87729 Replicon plasmid unnamed1
Accession NZ_CP019656
Organism Paenibacillus larvae subsp. larvae strain Eric_III

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ERICIII_RS23680 Protein ID WP_104932905.1
Coordinates 87400..87729 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ERICIII_RS23675 Protein ID WP_104932923.1
Coordinates 87164..87403 (+) Length 80 a.a.

Genomic Context

ERICIII_RS23665ERICIII_RS23675ERICIII_RS23680ERICIII_RS23685ERICIII_RS23700ERICIII_RS23670ERICIII_RS23690ERICIII_RS23695
Location: 83448..83702 (255 bp)
Type: Others
Protein ID: WP_104932922.1
Location: 87164..87403 (240 bp)
Type: Antitoxin
Protein ID: WP_104932923.1
Location: 87400..87729 (330 bp)
Type: Toxin
Protein ID: WP_104932905.1
Location: 87755..88045 (291 bp)
Type: Others
Protein ID: WP_104932906.1
Location: 89686..90990 (1305 bp)
Type: Others
Protein ID: WP_104932909.1
Location: 85186..85491 (306 bp)
Type: Others
Protein ID: WP_158672845.1
Location: 88288..88524 (237 bp)
Type: Others
Protein ID: WP_104932907.1
Location: 88508..89281 (774 bp)
Type: Others
Protein ID: WP_104932908.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ERICIII_RS2366583448..83702+255WP_104932922.1hypothetical protein-
ERICIII_RS2367085186..85491-306WP_158672845.1hypothetical protein-
ERICIII_RS2367587164..87403+240WP_104932923.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
ERICIII_RS2368087400..87729+330WP_104932905.1type II toxin-antitoxin system PemK/MazF family toxinToxin
ERICIII_RS2368587755..88045+291WP_104932906.1hypothetical protein-
ERICIII_RS2369088288..88524-237WP_104932907.1hypothetical protein-
ERICIII_RS2369588508..89281-774WP_104932908.1ParA family protein-
ERICIII_RS2370089686..90990+1305WP_104932909.1competence protein CoiA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..103273103273
-flankIS/Tn--91195..91944749


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-108)

Antitoxin

Antitoxin PemI-like

(1-79)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12450.45 Da        Isoelectric Point: 7.3585

>T73124 WP_104932905.1 NZ_CP019656:87400-87729 [Paenibacillus larvae subsp. larvae]
VTVVPDRGDIVYMDFNPQSGHEQAGWRPALVLSPKLFNATTNLAVVCPITSRVKDYLFEVHLPDTMKTKGVILVHQLKSA
DWKSRRLEIREKAPQEIIDEVIEKIHTFL

Download         Length: 330 bp

>T73124 NZ_CP019656:87400-87729 [Paenibacillus larvae subsp. larvae]
GTGACAGTTGTTCCAGATCGCGGTGATATCGTTTATATGGACTTTAATCCACAGAGCGGACATGAACAAGCCGGGTGGCG
ACCAGCCCTTGTACTGTCACCAAAATTATTTAATGCGACAACGAATCTTGCTGTAGTCTGCCCTATCACTTCACGGGTGA
AAGACTACTTATTTGAAGTTCATCTTCCAGACACTATGAAAACAAAAGGTGTTATACTTGTACACCAATTGAAAAGCGCT
GATTGGAAATCACGAAGATTAGAAATTCGGGAGAAAGCACCACAAGAAATTATTGACGAAGTAATCGAAAAGATTCATAC
TTTCCTATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9049.40 Da        Isoelectric Point: 6.7103

>AT73124 WP_104932923.1 NZ_CP019656:87164-87403 [Paenibacillus larvae subsp. larvae]
MSTLVRKWGNSLALRIPRHFAESLNLHEGSEVELKLTEDCLSVKPKKRKYTLEELCASIKDGNQHDLIDFGKPVGEEIW

Download         Length: 240 bp

>AT73124 NZ_CP019656:87164-87403 [Paenibacillus larvae subsp. larvae]
ATGAGTACGCTTGTGAGAAAATGGGGAAATAGCCTGGCACTTCGTATTCCCAGGCATTTTGCTGAAAGCTTAAATCTTCA
TGAAGGCTCTGAAGTTGAATTAAAGCTAACAGAAGACTGCTTGAGTGTCAAGCCGAAGAAGAGAAAGTATACCCTTGAGG
AACTTTGTGCTTCTATTAAAGACGGTAATCAGCATGACCTTATTGACTTCGGTAAACCTGTTGGGGAGGAAATTTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References