Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3736113..3736708 Replicon chromosome
Accession NZ_CP019655
Organism Paenibacillus larvae subsp. larvae strain Eric_III

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ERICIII_RS19345 Protein ID WP_077997555.1
Coordinates 3736415..3736708 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W2E434
Locus tag ERICIII_RS19340 Protein ID WP_036658190.1
Coordinates 3736113..3736382 (+) Length 90 a.a.

Genomic Context

ERICIII_RS19320ERICIII_RS19330ERICIII_RS19340ERICIII_RS19345ERICIII_RS19350ERICIII_RS19355ERICIII_RS19360ERICIII_RS19325ERICIII_RS19335
Location: 3731126..3731740 (615 bp)
Type: Others
Protein ID: WP_077996009.1
Location: 3733948..3735234 (1287 bp)
Type: Others
Protein ID: WP_077996011.1
Location: 3736113..3736382 (270 bp)
Type: Antitoxin
Protein ID: WP_036658190.1
Location: 3736415..3736708 (294 bp)
Type: Toxin
Protein ID: WP_077997555.1
Location: 3736960..3737250 (291 bp)
Type: Others
Protein ID: WP_023483432.1
Location: 3737247..3739757 (2511 bp)
Type: Others
Protein ID: WP_077996013.1
Location: 3739862..3740158 (297 bp)
Type: Others
Protein ID: WP_036658187.1
Location: 3731772..3733688 (1917 bp)
Type: Others
Protein ID: WP_077996010.1
Location: 3735462..3735794 (333 bp)
Type: Others
Protein ID: WP_077996012.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ERICIII_RS193203731126..3731740+615WP_077996009.1sigma-70 family RNA polymerase sigma factor-
ERICIII_RS193253731772..3733688-1917WP_077996010.1AAA family ATPase-
ERICIII_RS193303733948..3735234+1287WP_077996011.1MFS transporter-
ERICIII_RS193353735462..3735794-333WP_077996012.1hypothetical protein-
ERICIII_RS193403736113..3736382+270WP_036658190.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
ERICIII_RS193453736415..3736708+294WP_077997555.1type II toxin-antitoxin system PemK/MazF family toxinToxin
ERICIII_RS193503736960..3737250+291WP_023483432.1metalloregulator ArsR/SmtB family transcription factor-
ERICIII_RS193553737247..3739757+2511WP_077996013.1FAD-dependent oxidoreductase-
ERICIII_RS193603739862..3740158+297WP_036658187.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--3741261..37424841223


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-96)

Antitoxin

Antitoxin PemI-like

(11-89)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10996.75 Da        Isoelectric Point: 7.2775

>T73123 WP_077997555.1 NZ_CP019655:3736415-3736708 [Paenibacillus larvae subsp. larvae]
MDFNPQIGHEQAGRRPGLVVSPTSFNRVTGFIVVCPITRTVRNYPYEVPLPSDLMTEGVVLAHQVKSLDWKARKAEVREK
VPKEIIDDVLDLIHTFL

Download         Length: 294 bp

>T73123 NZ_CP019655:3736415-3736708 [Paenibacillus larvae subsp. larvae]
ATGGATTTTAACCCGCAGATTGGACATGAACAAGCCGGAAGAAGACCAGGCCTTGTTGTCTCTCCTACATCATTCAATAG
GGTAACAGGCTTTATAGTTGTATGCCCTATTACAAGAACCGTTAGGAATTATCCATATGAAGTTCCCCTCCCTTCCGATC
TTATGACCGAAGGTGTTGTTTTGGCTCATCAAGTAAAAAGCTTGGATTGGAAGGCAAGAAAGGCAGAAGTTCGGGAAAAA
GTACCAAAAGAAATTATTGACGATGTACTGGATTTAATTCACACTTTCCTATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10006.46 Da        Isoelectric Point: 5.7379

>AT73123 WP_036658190.1 NZ_CP019655:3736113-3736382 [Paenibacillus larvae subsp. larvae]
MGKDRERMSVMSTIVSKWGNSLAIRIPSNLAESLNIKEGSEVELSIMDSTLTIKPKKRKPTLEELLAKITDGNHHEEIDF
GKPEGNEVW

Download         Length: 270 bp

>AT73123 NZ_CP019655:3736113-3736382 [Paenibacillus larvae subsp. larvae]
ATGGGTAAAGACAGGGAAAGGATGAGTGTAATGAGCACAATTGTGAGCAAATGGGGAAACAGTCTCGCAATCCGCATTCC
AAGTAACCTGGCAGAAAGCCTAAACATAAAAGAGGGTTCTGAAGTTGAATTAAGCATCATGGATAGTACACTAACTATAA
AACCTAAAAAACGTAAGCCAACTCTCGAAGAATTACTGGCAAAAATAACAGACGGTAACCATCATGAGGAAATTGACTTT
GGAAAACCGGAGGGGAACGAGGTTTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2L1TQJ8

References