Detailed information of TA system TA073122

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-UPF0150
• Location: 3453781..3454425
• Replicon: chromosome
• Accession: NZ_CP019655
• Organism: Paenibacillus larvae subsp. larvae strain Eric_III

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: W2E6W9
• Locus tag: ERICIII_RS17785
• Protein ID: WP_036654551.1
• Coordinates: 3453781..3453984 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: ERICIII_RS17790
• Protein ID: WP_077995836.1
• Coordinates: 3454015..3454425 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ERICIII_RS17770	3450037..3450258	-	222	WP_077995833.1	hypothetical protein	-
ERICIII_RS17775	3450275..3452137	-	1863	WP_077995834.1	phage terminase large subunit family protein	-
ERICIII_RS17780	3452121..3452633	-	513	WP_077995835.1	hypothetical protein	-
ERICIII_RS17785	3453781..3453984	+	204	WP_036654551.1	type II toxin-antitoxin system HicA family toxin	Toxin
ERICIII_RS17790	3454015..3454425	+	411	WP_077995836.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ERICIII_RS17795	3454454..3454657	-	204	WP_077995837.1	hypothetical protein	-
ERICIII_RS17800	3454838..3454987	-	150	Protein_3507	response regulator transcription factor	-
ERICIII_RS17805	3455128..3456438	-	1311	WP_024094814.1	purine/pyrimidine permease	-
ERICIII_RS17810	3456577..3457509	-	933	WP_036654839.1	dihydroorotate dehydrogenase	-
ERICIII_RS17815	3457490..3458191	-	702	WP_077995841.1	dihydroorotate dehydrogenase electron transfer subunit	-
ERICIII_RS25295	3458419..3458523	-	105	WP_188318623.1	sporulation protein YjcZ	-
ERICIII_RS17820	3458607..3459134	+	528	WP_077997537.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3343701..3466451	122750

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (10-66)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-107)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7774.08 Da
• Isoelectric Point: 10.8900

>T73122 WP_036654551.1 NZ_CP019655:3453781-3453984 [Paenibacillus larvae subsp. larvae]
MVNLNKAYSSREVIKILKEDGWIHKNTEGDHWHFIHPTKKGKVTVPHPKKGLKRRTTKSIFEQAGLI

Nucleotide

• Length: 204 bp

>T73122 NZ_CP019655:3453781-3453984 [Paenibacillus larvae subsp. larvae]
ATGGTCAACCTCAATAAAGCATACTCATCAAGAGAGGTTATCAAAATCCTAAAAGAGGATGGCTGGATACATAAAAACAC
CGAAGGCGATCATTGGCACTTTATTCATCCCACTAAAAAAGGAAAGGTGACTGTACCCCATCCGAAAAAAGGCTTGAAAC
GTCGAACAACAAAAAGTATCTTTGAGCAGGCAGGGCTGATTTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 15121.91 Da
• Isoelectric Point: 4.0257

>AT73122 WP_077995836.1 NZ_CP019655:3454015-3454425 [Paenibacillus larvae subsp. larvae]
MKYIYPAVFTPGEPDEGGFTVTFPDLPGCITEGDDLEEALHMAKDALGGHLYLMEEDGDEIPRSSQPDSIQLETGEFVSL
IQANTDFIRERIQSKAVNKTVTLPKWLNDVAAEEGINFSQTLQDALKQKLEIKDFS

Nucleotide

• Length: 411 bp

>AT73122 NZ_CP019655:3454015-3454425 [Paenibacillus larvae subsp. larvae]
ATGAAATACATTTACCCTGCTGTTTTTACCCCCGGCGAACCAGACGAAGGAGGCTTTACTGTCACATTCCCTGATCTTCC
TGGATGCATCACAGAAGGCGATGATCTGGAAGAAGCCCTACACATGGCAAAAGATGCTCTTGGCGGCCATTTATACCTGA
TGGAAGAGGATGGCGACGAAATACCTCGTTCATCACAACCAGACTCTATACAGCTTGAAACTGGAGAATTTGTTTCTCTT
ATTCAGGCTAATACAGATTTCATCCGCGAAAGGATTCAGAGTAAAGCCGTGAATAAGACCGTCACTCTTCCAAAATGGCT
TAATGATGTAGCAGCGGAAGAAGGCATTAACTTTTCTCAGACTCTTCAGGATGCATTAAAACAAAAGCTTGAAATCAAAG
ACTTCTCCTAA

Structures

Toxin

• AlphaFold DB: A0A2L1UH89