Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 3818535..3819161 Replicon chromosome
Accession NZ_CP019651
Organism Paenibacillus larvae subsp. larvae strain ERIC_I

Toxin (Protein)


Gene name pemK Uniprot ID V9W2Z1
Locus tag ERICI_RS19855 Protein ID WP_023485406.1
Coordinates 3818535..3818885 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ERICI_RS19860 Protein ID WP_172423825.1
Coordinates 3818889..3819161 (-) Length 91 a.a.

Genomic Context

ERICI_RS19845ERICI_RS19835ERICI_RS19840ERICI_RS19850ERICI_RS19855ERICI_RS19860ERICI_RS19865ERICI_RS19870ERICI_RS19880
Location: 3815391..3815957 (567 bp)
Type: Others
Protein ID: WP_036657428.1
Location: 3813716..3813943 (228 bp)
Type: Others
Protein ID: WP_036655907.1
Location: 3814535..3814993 (459 bp)
Type: Others
Protein ID: WP_023485404.1
Location: 3816159..3818363 (2205 bp)
Type: Others
Protein ID: WP_046655196.1
Location: 3818535..3818885 (351 bp)
Type: Toxin
Protein ID: WP_023485406.1
Location: 3818889..3819161 (273 bp)
Type: Antitoxin
Protein ID: WP_172423825.1
Location: 3819405..3820592 (1188 bp)
Type: Others
Protein ID: WP_023485408.1
Location: 3820760..3822016 (1257 bp)
Type: Others
Protein ID: WP_024093122.1
Location: 3822561..3822767 (207 bp)
Type: Others
Protein ID: WP_144029578.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ERICI_RS198353813716..3813943-228WP_036655907.1hypothetical protein-
ERICI_RS198403814535..3814993-459WP_023485404.1hypothetical protein-
ERICI_RS198453815391..3815957+567WP_036657428.1sigma-70 family RNA polymerase sigma factor-
ERICI_RS198503816159..3818363-2205WP_046655196.1RNA-binding transcriptional accessory protein-
ERICI_RS198553818535..3818885-351WP_023485406.1type II toxin-antitoxin system PemK/MazF family toxinToxin
ERICI_RS198603818889..3819161-273WP_172423825.1ribbon-helix-helix protein, CopG familyAntitoxin
ERICI_RS198653819405..3820592-1188WP_023485408.1alanine racemase-
ERICI_RS198703820760..3822016-1257WP_024093122.1outer membrane lipoprotein carrier protein LolA-
ERICI_RS198803822561..3822767-207WP_144029578.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-42)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12877.80 Da        Isoelectric Point: 5.1393

>T73119 WP_023485406.1 NZ_CP019651:c3818885-3818535 [Paenibacillus larvae subsp. larvae]
MIVKRGDVFFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAETHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEDTMRKVNDALQVSVGLIEF

Download         Length: 351 bp

>T73119 NZ_CP019651:c3818885-3818535 [Paenibacillus larvae subsp. larvae]
TTGATTGTCAAACGTGGTGATGTTTTCTTTGCGGATCTTTCTCCTGTTGTCGGTTCCGAGCAGGGGGGAGTGAGGCCTGT
TCTTATCATTCAGAACGATATCGGGAACCGGTTTAGCCCGACGGTAATCGTGGCGGCGATTACCGCCCAAATTCAAAAAG
CCAAGCTGCCCACTCATGTGGAGATCGATGCGGAAACACACGGATTTGACCGCGATTCGGTTATCTTGCTGGAACAGATC
CGGACCATTGACAAGCAGCGGTTGACCGATAAAATTACCCATTTAGATGAAGATACCATGCGTAAAGTGAACGATGCTTT
ACAGGTAAGTGTAGGGTTGATAGAATTTTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10556.15 Da        Isoelectric Point: 7.2048

>AT73119 WP_172423825.1 NZ_CP019651:c3819161-3818889 [Paenibacillus larvae subsp. larvae]
MHNTKRIMISLPDHLLKEVDGIVEKENSNRSEFIRQAMRLYLLERKKRTLRESMQRGYMEMAKINLNMASEAFQAEEEAD
NTVDRLVSGV

Download         Length: 273 bp

>AT73119 NZ_CP019651:c3819161-3818889 [Paenibacillus larvae subsp. larvae]
ATGCATAATACGAAGCGTATCATGATTAGTCTTCCAGACCACCTTCTGAAGGAGGTGGACGGCATCGTCGAGAAAGAAAA
CTCGAATCGCAGCGAGTTCATTCGACAAGCCATGAGATTGTACCTGCTCGAAAGAAAGAAGAGGACCCTCCGTGAATCCA
TGCAGAGAGGCTATATGGAAATGGCGAAAATTAATTTAAATATGGCGTCCGAAGCTTTTCAAGCGGAGGAAGAAGCCGAC
AATACGGTGGACCGCTTAGTGAGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2L1TT28

Antitoxin

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Source
ID
Structure
No matching records found

References