Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel2-ATphRel2/DUF4065(antitoxin)
Location 1548653..1550100 Replicon chromosome
Accession NZ_CP019651
Organism Paenibacillus larvae subsp. larvae strain ERIC_I

Toxin (Protein)


Gene name phRel2 Uniprot ID -
Locus tag ERICI_RS08140 Protein ID WP_046655328.1
Coordinates 1549405..1550100 (-) Length 232 a.a.

Antitoxin (Protein)


Gene name ATphRel2 Uniprot ID W2EHL1
Locus tag ERICI_RS08135 Protein ID WP_023483534.1
Coordinates 1548653..1549402 (-) Length 250 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ERICI_RS08120 1545292..1546359 + 1068 WP_051428031.1 XRE family transcriptional regulator -
ERICI_RS08125 1546608..1547090 + 483 WP_024094407.1 SocA family protein -
ERICI_RS08130 1547292..1547843 - 552 WP_024094406.1 hypothetical protein -
ERICI_RS08135 1548653..1549402 - 750 WP_023483534.1 DUF4065 domain-containing protein Antitoxin
ERICI_RS08140 1549405..1550100 - 696 WP_046655328.1 hypothetical protein Toxin
ERICI_RS08150 1550916..1552478 + 1563 WP_036654894.1 M4 family metallopeptidase -
ERICI_RS08155 1553232..1553471 + 240 WP_036656501.1 hypothetical protein -
ERICI_RS08160 1553911..1554189 + 279 WP_144029638.1 hypothetical protein -
ERICI_RS22470 1554202..1554483 + 282 WP_144029639.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1498227..1557790 59563


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(99-206)

Antitoxin

Antitoxin SocA-like, Panacea domain

(113-225)


Sequences

Toxin        


Download         Length: 232 a.a.        Molecular weight: 27728.80 Da        Isoelectric Point: 8.5708

>T73116 WP_046655328.1 NZ_CP019651:c1550100-1549405 [Paenibacillus larvae subsp. larvae]
MDFSQRLGTIISIDYKPIIHLITEISDIHGEFSNEYLKECRNRLINMKKQLVRDTFEDGLNIVKEDFYSLVQNYHEMLRA
FIVETELEYDYADLHLRMRVKQMESIMHKLIFYKTGKKEEGKVPINKCLNDLLGIRILIGGFDYNCNKFNDLYQKIKSTH
KIKIENRSIEGYRGTHIYFYVNNQAFPWELQIWNKAHEKENEQLHKTHKSKREYIKWPNTYKNSKEHEGGV

Download         Length: 696 bp

>T73116 NZ_CP019651:c1550100-1549405 [Paenibacillus larvae subsp. larvae]
ATGGATTTCAGTCAGCGGTTAGGAACTATTATAAGCATTGATTACAAACCTATAATACACTTGATAACTGAAATTAGTGA
TATACATGGAGAATTCTCAAATGAATATTTAAAAGAATGTAGAAACCGGTTAATAAATATGAAGAAACAGTTGGTTAGGG
ATACCTTTGAAGATGGACTTAATATTGTCAAAGAGGATTTTTATTCTTTAGTCCAAAATTATCATGAGATGCTTAGAGCC
TTCATTGTTGAAACTGAATTGGAATATGATTATGCCGATTTGCATTTGCGCATGAGAGTGAAACAAATGGAATCAATAAT
GCATAAATTGATTTTTTATAAGACAGGAAAAAAAGAGGAAGGGAAAGTTCCAATAAACAAGTGTTTGAATGATTTATTGG
GAATCAGAATATTAATTGGCGGATTTGACTACAATTGTAATAAATTCAATGACTTGTATCAAAAAATAAAGTCGACTCAT
AAAATAAAAATAGAAAATAGATCCATTGAGGGTTATCGAGGTACTCATATTTATTTTTATGTTAATAATCAAGCTTTTCC
TTGGGAACTTCAAATATGGAATAAAGCGCATGAGAAGGAAAATGAACAATTACATAAAACACATAAAAGTAAACGCGAGT
ACATAAAATGGCCTAATACATATAAAAATTCAAAAGAACATGAAGGAGGTGTTTGA

Antitoxin


Download         Length: 250 a.a.        Molecular weight: 28969.38 Da        Isoelectric Point: 6.9799

>AT73116 WP_023483534.1 NZ_CP019651:c1549402-1548653 [Paenibacillus larvae subsp. larvae]
MAFHFVAIMSNYVKGMRIGWHYASEGKLDKALIKQFMSRVEEKYSDAQLGIHKIATDSVTWRSVVEKDSFFEDVFVTTDI
EKFVRLIAEDQELKAYDVAKFIVSTVQVSHLKLQKLLYYVYADFLLATGKKLFKEPIVAFEYGPVVEEVFHKYKVHGSSE
IDYKEDEYFCIYTDEFAVTPSFMRVASSEHGIYAVGFILKVLDKYESYSAGELVKKTHQVGGPWKRVYVKGMNYEITDEL
IKRYHKFVQ

Download         Length: 750 bp

>AT73116 NZ_CP019651:c1549402-1548653 [Paenibacillus larvae subsp. larvae]
ATGGCATTTCACTTTGTAGCAATAATGAGTAACTATGTAAAAGGAATGCGTATCGGCTGGCATTATGCTTCAGAGGGGAA
ACTTGACAAAGCTTTGATAAAGCAATTTATGAGTAGAGTCGAGGAAAAATATAGTGATGCTCAATTAGGCATTCACAAAA
TTGCTACAGATTCTGTTACTTGGCGATCAGTCGTAGAAAAAGATTCATTTTTCGAGGATGTTTTTGTAACGACTGATATA
GAAAAATTTGTTAGGCTTATAGCAGAAGATCAGGAATTAAAGGCCTATGATGTAGCTAAATTTATAGTATCCACTGTACA
AGTATCACATTTAAAATTGCAGAAGCTGTTATACTATGTATATGCAGATTTTTTACTGGCTACAGGCAAAAAGTTATTCA
AAGAACCAATTGTAGCATTTGAATACGGCCCAGTGGTAGAAGAGGTTTTTCATAAATATAAGGTTCATGGTTCTTCTGAA
ATTGATTATAAAGAAGATGAGTATTTTTGTATTTATACGGATGAATTCGCCGTTACACCTTCTTTCATGAGAGTAGCATC
TTCTGAGCATGGTATTTATGCGGTTGGATTCATATTAAAGGTCCTAGATAAATACGAGTCATATTCAGCAGGAGAACTTG
TTAAAAAAACACATCAAGTAGGAGGCCCTTGGAAAAGGGTTTATGTAAAAGGAATGAATTATGAAATTACGGATGAATTG
ATCAAGAGATACCATAAATTTGTTCAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W2EHL1

References