Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel2-ATphRel2/DUF4065(antitoxin)
Location 1548653..1550100 Replicon chromosome
Accession NZ_CP019651
Organism Paenibacillus larvae subsp. larvae strain ERIC_I

Toxin (Protein)


Gene name phRel2 Uniprot ID -
Locus tag ERICI_RS08140 Protein ID WP_046655328.1
Coordinates 1549405..1550100 (-) Length 232 a.a.

Antitoxin (Protein)


Gene name ATphRel2 Uniprot ID W2EHL1
Locus tag ERICI_RS08135 Protein ID WP_023483534.1
Coordinates 1548653..1549402 (-) Length 250 a.a.

Genomic Context

ERICI_RS08120ERICI_RS08125ERICI_RS08150ERICI_RS08155ERICI_RS08160ERICI_RS22470ERICI_RS08130ERICI_RS08135ERICI_RS08140
Location: 1545292..1546359 (1068 bp)
Type: Others
Protein ID: WP_051428031.1
Location: 1546608..1547090 (483 bp)
Type: Others
Protein ID: WP_024094407.1
Location: 1550916..1552478 (1563 bp)
Type: Others
Protein ID: WP_036654894.1
Location: 1553232..1553471 (240 bp)
Type: Others
Protein ID: WP_036656501.1
Location: 1553911..1554189 (279 bp)
Type: Others
Protein ID: WP_144029638.1
Location: 1554202..1554483 (282 bp)
Type: Others
Protein ID: WP_144029639.1
Location: 1547292..1547843 (552 bp)
Type: Others
Protein ID: WP_024094406.1
Location: 1548653..1549402 (750 bp)
Type: Antitoxin
Protein ID: WP_023483534.1
Location: 1549405..1550100 (696 bp)
Type: Toxin
Protein ID: WP_046655328.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ERICI_RS081201545292..1546359+1068WP_051428031.1XRE family transcriptional regulator-
ERICI_RS081251546608..1547090+483WP_024094407.1SocA family protein-
ERICI_RS081301547292..1547843-552WP_024094406.1hypothetical protein-
ERICI_RS081351548653..1549402-750WP_023483534.1DUF4065 domain-containing proteinAntitoxin
ERICI_RS081401549405..1550100-696WP_046655328.1hypothetical proteinToxin
ERICI_RS081501550916..1552478+1563WP_036654894.1M4 family metallopeptidase-
ERICI_RS081551553232..1553471+240WP_036656501.1hypothetical protein-
ERICI_RS081601553911..1554189+279WP_144029638.1hypothetical protein-
ERICI_RS224701554202..1554483+282WP_144029639.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1498227..155779059563


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(99-206)

Antitoxin

Antitoxin SocA-like, Panacea domain

(113-225)


Sequences

Toxin        


Download         Length: 232 a.a.        Molecular weight: 27728.80 Da        Isoelectric Point: 8.5708

>T73116 WP_046655328.1 NZ_CP019651:c1550100-1549405 [Paenibacillus larvae subsp. larvae]
MDFSQRLGTIISIDYKPIIHLITEISDIHGEFSNEYLKECRNRLINMKKQLVRDTFEDGLNIVKEDFYSLVQNYHEMLRA
FIVETELEYDYADLHLRMRVKQMESIMHKLIFYKTGKKEEGKVPINKCLNDLLGIRILIGGFDYNCNKFNDLYQKIKSTH
KIKIENRSIEGYRGTHIYFYVNNQAFPWELQIWNKAHEKENEQLHKTHKSKREYIKWPNTYKNSKEHEGGV

Download         Length: 696 bp

>T73116 NZ_CP019651:c1550100-1549405 [Paenibacillus larvae subsp. larvae]
ATGGATTTCAGTCAGCGGTTAGGAACTATTATAAGCATTGATTACAAACCTATAATACACTTGATAACTGAAATTAGTGA
TATACATGGAGAATTCTCAAATGAATATTTAAAAGAATGTAGAAACCGGTTAATAAATATGAAGAAACAGTTGGTTAGGG
ATACCTTTGAAGATGGACTTAATATTGTCAAAGAGGATTTTTATTCTTTAGTCCAAAATTATCATGAGATGCTTAGAGCC
TTCATTGTTGAAACTGAATTGGAATATGATTATGCCGATTTGCATTTGCGCATGAGAGTGAAACAAATGGAATCAATAAT
GCATAAATTGATTTTTTATAAGACAGGAAAAAAAGAGGAAGGGAAAGTTCCAATAAACAAGTGTTTGAATGATTTATTGG
GAATCAGAATATTAATTGGCGGATTTGACTACAATTGTAATAAATTCAATGACTTGTATCAAAAAATAAAGTCGACTCAT
AAAATAAAAATAGAAAATAGATCCATTGAGGGTTATCGAGGTACTCATATTTATTTTTATGTTAATAATCAAGCTTTTCC
TTGGGAACTTCAAATATGGAATAAAGCGCATGAGAAGGAAAATGAACAATTACATAAAACACATAAAAGTAAACGCGAGT
ACATAAAATGGCCTAATACATATAAAAATTCAAAAGAACATGAAGGAGGTGTTTGA

Antitoxin


Download         Length: 250 a.a.        Molecular weight: 28969.38 Da        Isoelectric Point: 6.9799

>AT73116 WP_023483534.1 NZ_CP019651:c1549402-1548653 [Paenibacillus larvae subsp. larvae]
MAFHFVAIMSNYVKGMRIGWHYASEGKLDKALIKQFMSRVEEKYSDAQLGIHKIATDSVTWRSVVEKDSFFEDVFVTTDI
EKFVRLIAEDQELKAYDVAKFIVSTVQVSHLKLQKLLYYVYADFLLATGKKLFKEPIVAFEYGPVVEEVFHKYKVHGSSE
IDYKEDEYFCIYTDEFAVTPSFMRVASSEHGIYAVGFILKVLDKYESYSAGELVKKTHQVGGPWKRVYVKGMNYEITDEL
IKRYHKFVQ

Download         Length: 750 bp

>AT73116 NZ_CP019651:c1549402-1548653 [Paenibacillus larvae subsp. larvae]
ATGGCATTTCACTTTGTAGCAATAATGAGTAACTATGTAAAAGGAATGCGTATCGGCTGGCATTATGCTTCAGAGGGGAA
ACTTGACAAAGCTTTGATAAAGCAATTTATGAGTAGAGTCGAGGAAAAATATAGTGATGCTCAATTAGGCATTCACAAAA
TTGCTACAGATTCTGTTACTTGGCGATCAGTCGTAGAAAAAGATTCATTTTTCGAGGATGTTTTTGTAACGACTGATATA
GAAAAATTTGTTAGGCTTATAGCAGAAGATCAGGAATTAAAGGCCTATGATGTAGCTAAATTTATAGTATCCACTGTACA
AGTATCACATTTAAAATTGCAGAAGCTGTTATACTATGTATATGCAGATTTTTTACTGGCTACAGGCAAAAAGTTATTCA
AAGAACCAATTGTAGCATTTGAATACGGCCCAGTGGTAGAAGAGGTTTTTCATAAATATAAGGTTCATGGTTCTTCTGAA
ATTGATTATAAAGAAGATGAGTATTTTTGTATTTATACGGATGAATTCGCCGTTACACCTTCTTTCATGAGAGTAGCATC
TTCTGAGCATGGTATTTATGCGGTTGGATTCATATTAAAGGTCCTAGATAAATACGAGTCATATTCAGCAGGAGAACTTG
TTAAAAAAACACATCAAGTAGGAGGCCCTTGGAAAAGGGTTTATGTAAAAGGAATGAATTATGAAATTACGGATGAATTG
ATCAAGAGATACCATAAATTTGTTCAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBW2EHL1

References