Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel2-ATphRel2/DUF4065(antitoxin)
Location 1077456..1078903 Replicon chromosome
Accession NZ_CP019651
Organism Paenibacillus larvae subsp. larvae strain ERIC_I

Toxin (Protein)


Gene name phRel2 Uniprot ID -
Locus tag ERICI_RS05565 Protein ID WP_046655328.1
Coordinates 1078208..1078903 (-) Length 232 a.a.

Antitoxin (Protein)


Gene name ATphRel2 Uniprot ID W2EHL1
Locus tag ERICI_RS05560 Protein ID WP_023483534.1
Coordinates 1077456..1078205 (-) Length 250 a.a.

Genomic Context

ERICI_RS05545ERICI_RS05550ERICI_RS05575ERICI_RS05585ERICI_RS05555ERICI_RS05560ERICI_RS05565ERICI_RS05580
Location: 1074095..1075162 (1068 bp)
Type: Others
Protein ID: WP_051428031.1
Location: 1075411..1075893 (483 bp)
Type: Others
Protein ID: WP_024094407.1
Location: 1079719..1081281 (1563 bp)
Type: Others
Protein ID: WP_036654894.1
Location: 1083367..1083681 (315 bp)
Type: Others
Protein ID: WP_036654891.1
Location: 1076095..1076646 (552 bp)
Type: Others
Protein ID: WP_024094406.1
Location: 1077456..1078205 (750 bp)
Type: Antitoxin
Protein ID: WP_023483534.1
Location: 1078208..1078903 (696 bp)
Type: Toxin
Protein ID: WP_046655328.1
Location: 1081693..1082916 (1224 bp)
Type: Others
Protein ID: WP_023483236.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ERICI_RS055451074095..1075162+1068WP_051428031.1XRE family transcriptional regulator-
ERICI_RS055501075411..1075893+483WP_024094407.1SocA family protein-
ERICI_RS055551076095..1076646-552WP_024094406.1hypothetical protein-
ERICI_RS055601077456..1078205-750WP_023483534.1DUF4065 domain-containing proteinAntitoxin
ERICI_RS055651078208..1078903-696WP_046655328.1hypothetical proteinToxin
ERICI_RS055751079719..1081281+1563WP_036654894.1M4 family metallopeptidase-
ERICI_RS055801081693..1082916-1224WP_023483236.1IS256 family transposase-
ERICI_RS055851083367..1083681+315WP_036654891.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1067390..107896911579
-flankIS/Tn--1081693..10829161223


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(99-206)

Antitoxin

Antitoxin SocA-like, Panacea domain

(113-225)


Sequences

Toxin        


Download         Length: 232 a.a.        Molecular weight: 27728.80 Da        Isoelectric Point: 8.5708

>T73115 WP_046655328.1 NZ_CP019651:c1078903-1078208 [Paenibacillus larvae subsp. larvae]
MDFSQRLGTIISIDYKPIIHLITEISDIHGEFSNEYLKECRNRLINMKKQLVRDTFEDGLNIVKEDFYSLVQNYHEMLRA
FIVETELEYDYADLHLRMRVKQMESIMHKLIFYKTGKKEEGKVPINKCLNDLLGIRILIGGFDYNCNKFNDLYQKIKSTH
KIKIENRSIEGYRGTHIYFYVNNQAFPWELQIWNKAHEKENEQLHKTHKSKREYIKWPNTYKNSKEHEGGV

Download         Length: 696 bp

>T73115 NZ_CP019651:c1078903-1078208 [Paenibacillus larvae subsp. larvae]
ATGGATTTCAGTCAGCGGTTAGGAACTATTATAAGCATTGATTACAAACCTATAATACACTTGATAACTGAAATTAGTGA
TATACATGGAGAATTCTCAAATGAATATTTAAAAGAATGTAGAAACCGGTTAATAAATATGAAGAAACAGTTGGTTAGGG
ATACCTTTGAAGATGGACTTAATATTGTCAAAGAGGATTTTTATTCTTTAGTCCAAAATTATCATGAGATGCTTAGAGCC
TTCATTGTTGAAACTGAATTGGAATATGATTATGCCGATTTGCATTTGCGCATGAGAGTGAAACAAATGGAATCAATAAT
GCATAAATTGATTTTTTATAAGACAGGAAAAAAAGAGGAAGGGAAAGTTCCAATAAACAAGTGTTTGAATGATTTATTGG
GAATCAGAATATTAATTGGCGGATTTGACTACAATTGTAATAAATTCAATGACTTGTATCAAAAAATAAAGTCGACTCAT
AAAATAAAAATAGAAAATAGATCCATTGAGGGTTATCGAGGTACTCATATTTATTTTTATGTTAATAATCAAGCTTTTCC
TTGGGAACTTCAAATATGGAATAAAGCGCATGAGAAGGAAAATGAACAATTACATAAAACACATAAAAGTAAACGCGAGT
ACATAAAATGGCCTAATACATATAAAAATTCAAAAGAACATGAAGGAGGTGTTTGA

Antitoxin


Download         Length: 250 a.a.        Molecular weight: 28969.38 Da        Isoelectric Point: 6.9799

>AT73115 WP_023483534.1 NZ_CP019651:c1078205-1077456 [Paenibacillus larvae subsp. larvae]
MAFHFVAIMSNYVKGMRIGWHYASEGKLDKALIKQFMSRVEEKYSDAQLGIHKIATDSVTWRSVVEKDSFFEDVFVTTDI
EKFVRLIAEDQELKAYDVAKFIVSTVQVSHLKLQKLLYYVYADFLLATGKKLFKEPIVAFEYGPVVEEVFHKYKVHGSSE
IDYKEDEYFCIYTDEFAVTPSFMRVASSEHGIYAVGFILKVLDKYESYSAGELVKKTHQVGGPWKRVYVKGMNYEITDEL
IKRYHKFVQ

Download         Length: 750 bp

>AT73115 NZ_CP019651:c1078205-1077456 [Paenibacillus larvae subsp. larvae]
ATGGCATTTCACTTTGTAGCAATAATGAGTAACTATGTAAAAGGAATGCGTATCGGCTGGCATTATGCTTCAGAGGGGAA
ACTTGACAAAGCTTTGATAAAGCAATTTATGAGTAGAGTCGAGGAAAAATATAGTGATGCTCAATTAGGCATTCACAAAA
TTGCTACAGATTCTGTTACTTGGCGATCAGTCGTAGAAAAAGATTCATTTTTCGAGGATGTTTTTGTAACGACTGATATA
GAAAAATTTGTTAGGCTTATAGCAGAAGATCAGGAATTAAAGGCCTATGATGTAGCTAAATTTATAGTATCCACTGTACA
AGTATCACATTTAAAATTGCAGAAGCTGTTATACTATGTATATGCAGATTTTTTACTGGCTACAGGCAAAAAGTTATTCA
AAGAACCAATTGTAGCATTTGAATACGGCCCAGTGGTAGAAGAGGTTTTTCATAAATATAAGGTTCATGGTTCTTCTGAA
ATTGATTATAAAGAAGATGAGTATTTTTGTATTTATACGGATGAATTCGCCGTTACACCTTCTTTCATGAGAGTAGCATC
TTCTGAGCATGGTATTTATGCGGTTGGATTCATATTAAAGGTCCTAGATAAATACGAGTCATATTCAGCAGGAGAACTTG
TTAAAAAAACACATCAAGTAGGAGGCCCTTGGAAAAGGGTTTATGTAAAAGGAATGAATTATGAAATTACGGATGAATTG
ATCAAGAGATACCATAAATTTGTTCAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBW2EHL1

References