73114

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3659862..3661558 Replicon chromosome
Accession NZ_CP019650
Organism Microbulbifer agarilyticus strain GP101

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag Mag101_RS15235 Protein ID WP_077406921.1
Coordinates 3660200..3661558 (+) Length 453 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag Mag101_RS15230 Protein ID WP_077406918.1
Coordinates 3659862..3660206 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Mag101_RS15220 3655844..3657826 - 1983 WP_198040004.1 S9 family peptidase -
Mag101_RS15225 3658020..3659507 - 1488 WP_077406915.1 MFS transporter -
Mag101_RS15230 3659862..3660206 + 345 WP_077406918.1 helix-turn-helix domain-containing protein Antitoxin
Mag101_RS15235 3660200..3661558 + 1359 WP_077406921.1 type II toxin-antitoxin system HipA family toxin Toxin
Mag101_RS15240 3661730..3662902 + 1173 WP_077406924.1 AAA family ATPase -
Mag101_RS15245 3662899..3663642 + 744 WP_077406928.1 HNH endonuclease -
Mag101_RS15250 3663701..3664375 + 675 WP_077406931.1 penicillin-insensitive murein endopeptidase -
Mag101_RS15255 3664473..3665117 + 645 WP_077406934.1 hypothetical protein -
Mag101_RS15260 3665154..3665492 + 339 WP_077406937.1 cupin domain-containing protein -
Mag101_RS15265 3665541..3666002 + 462 WP_198040181.1 FAD-binding oxidoreductase -
Mag101_RS15270 3666050..3666499 + 450 WP_077406943.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(21-127)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 453 a.a.        Molecular weight: 50355.95 Da        Isoelectric Point: 6.3237

>T73114 WP_077406921.1 NZ_CP019650:3660200-3661558 [Microbulbifer agarilyticus]
MVMEVISVHLPDGHGPDGEAKSHNVGAVSFDTDTGLGAFEYTPEFIDTGIELSPLKMPLAKRIYSFPQLSFDTYRGLNGM
IADSLPDDFGNAVLNAWMAAQGKQPADITPLQRLQYTGKRGMGALEYAPATRLKHLNASQHIAIDELVGIAQEVLDSRAG
FQVNLGPNGNDERAAHPEEMLALLSVGMSAGGARPKAVLAFNQDFTEVRSGQTDVPEGFTHYLMKFDGVSEHNKNKETFG
DPMGFGAMEYVYYKMATACGIHMMPSHLLTEGDRRHFITERFDRRGNHKTHIQTLNGIAHVDYKVPGSYSYGELFAVARQ
LKLPATDAEQLLRRMVFNIVARNHDDHAKNFAFQLNGKTWQLAPAYDLAYSYKPGSRWVNSHWMSLNGKRDDFSREDLYS
LEAVSPLFSKRKIDGVVEEVVEQVSNWRQLAKVHNVPVSLIDEVEGNLRIIL

Download         Length: 1359 bp

>T73114 NZ_CP019650:3660200-3661558 [Microbulbifer agarilyticus]
ATGGTAATGGAAGTCATCAGCGTGCACCTGCCGGACGGCCACGGCCCCGATGGCGAGGCCAAGAGCCACAACGTCGGCGC
CGTCAGCTTTGATACCGACACCGGCCTCGGCGCCTTCGAATACACCCCCGAATTTATCGACACCGGCATCGAACTGTCGC
CACTCAAGATGCCGCTGGCCAAGCGCATCTATTCTTTCCCGCAGCTCAGCTTCGACACCTACCGCGGCCTGAACGGCATG
ATTGCCGACTCCCTGCCGGACGACTTCGGCAACGCGGTACTGAATGCGTGGATGGCCGCCCAGGGCAAACAGCCCGCAGA
CATCACCCCACTGCAACGGCTGCAATACACCGGCAAGCGCGGCATGGGCGCACTGGAATACGCCCCCGCTACTCGCCTCA
AACACCTGAACGCCTCCCAGCACATCGCCATCGATGAACTGGTGGGCATTGCCCAGGAAGTGCTCGACAGCCGCGCCGGC
TTTCAAGTGAACCTGGGCCCGAACGGCAACGACGAGCGCGCCGCCCACCCGGAAGAAATGCTCGCCCTGCTCTCCGTCGG
CATGAGCGCCGGCGGTGCCCGCCCCAAGGCGGTACTCGCGTTTAACCAGGACTTCACCGAAGTGCGCTCCGGGCAGACCG
ACGTACCGGAAGGCTTCACCCACTACCTGATGAAGTTCGACGGCGTAAGCGAACACAACAAAAACAAAGAAACCTTCGGC
GACCCCATGGGCTTCGGCGCCATGGAATACGTCTACTACAAAATGGCCACCGCCTGCGGCATCCATATGATGCCCAGCCA
CCTGCTCACCGAAGGCGACCGCCGGCACTTTATTACCGAACGCTTCGACCGCCGCGGCAACCACAAGACCCATATCCAGA
CCTTAAACGGCATTGCCCACGTGGATTACAAGGTGCCCGGCTCTTACTCCTACGGCGAACTCTTCGCCGTGGCGCGGCAA
CTGAAACTCCCCGCCACCGATGCCGAACAATTGCTGCGACGTATGGTATTCAACATCGTTGCCCGCAACCACGACGACCA
CGCAAAGAACTTCGCCTTCCAACTCAACGGCAAAACCTGGCAGTTGGCCCCCGCCTACGACCTCGCCTACAGCTACAAAC
CCGGCAGCCGCTGGGTGAACAGCCACTGGATGAGCTTGAACGGCAAGCGTGATGATTTTAGCCGCGAGGATTTATACAGC
CTGGAAGCGGTGAGCCCGCTGTTTAGTAAGCGGAAGATTGATGGGGTTGTTGAGGAAGTGGTGGAGCAGGTTTCGAACTG
GAGACAGCTGGCAAAGGTACACAATGTACCAGTGTCGCTGATCGATGAAGTCGAAGGGAACTTGAGGATTATTCTGTAG

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12484.19 Da        Isoelectric Point: 5.8632

>AT73114 WP_077406918.1 NZ_CP019650:3659862-3660206 [Microbulbifer agarilyticus]
MDYIAKSPAAVAELLGQRLKQARLNLDLTQLEVAERAGVGRKAVMNAEKGKVQLEALVAILQALDLTTQLDNFLPPQPPS
PVQLAKLQGKQRQRASGQHKQEGDQDTDEDTTAW

Download         Length: 345 bp

>AT73114 NZ_CP019650:3659862-3660206 [Microbulbifer agarilyticus]
ATGGACTACATCGCGAAATCCCCTGCCGCCGTTGCCGAGCTCCTCGGCCAGCGCCTGAAGCAGGCCCGCCTCAACCTCGA
CCTCACCCAACTGGAGGTGGCCGAGCGTGCCGGCGTGGGCCGCAAAGCGGTAATGAATGCGGAGAAAGGCAAGGTCCAGC
TGGAAGCGCTGGTCGCCATACTCCAGGCCCTCGACCTCACCACCCAGCTGGATAACTTCCTGCCACCCCAGCCCCCCTCG
CCGGTACAACTGGCCAAACTCCAGGGCAAACAGCGGCAACGGGCCTCCGGCCAGCACAAGCAAGAGGGCGATCAAGACAC
GGATGAGGACACGACCGCATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References