Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2577802..2578427 Replicon chromosome
Accession NZ_CP019646
Organism Limihaloglobus sulfuriphilus strain SM-Chi-D1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SMSP2_RS09820 Protein ID WP_146683781.1
Coordinates 2577802..2578200 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SMSP2_RS09825 Protein ID WP_146683782.1
Coordinates 2578197..2578427 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMSP2_RS09795 2573788..2574423 + 636 WP_146683776.1 sulfur carrier protein ThiS adenylyltransferase ThiF -
SMSP2_RS09800 2574424..2574636 + 213 WP_146683777.1 sulfur carrier protein ThiS -
SMSP2_RS09805 2574682..2575458 + 777 WP_146683778.1 thiazole synthase -
SMSP2_RS09810 2575483..2576631 + 1149 WP_146683779.1 2-iminoacetate synthase ThiH -
SMSP2_RS09815 2576639..2577760 - 1122 WP_146683780.1 anaerobic sulfatase maturase -
SMSP2_RS09820 2577802..2578200 - 399 WP_146683781.1 type II toxin-antitoxin system VapC family toxin Toxin
SMSP2_RS09825 2578197..2578427 - 231 WP_146683782.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SMSP2_RS09830 2578565..2579047 - 483 WP_186804671.1 NYN domain-containing protein -
SMSP2_RS09835 2579049..2580344 - 1296 WP_146683784.1 dihydroorotase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14706.13 Da        Isoelectric Point: 5.7079

>T73113 WP_146683781.1 NZ_CP019646:c2578200-2577802 [Limihaloglobus sulfuriphilus]
MIYMLDTNICIDMIRKPQSRALAHIQQYRPGDIAISAITLAELEFGVQKSSDPARNTLLLIKACSVLEILPFDNDAAAAY
GIVRCQLESKGTPIGPFDTLIAAHAMSQELTLVTNNMKEFNRIKDLKVENWI

Download         Length: 399 bp

>T73113 NZ_CP019646:c2578200-2577802 [Limihaloglobus sulfuriphilus]
ATGATTTACATGCTCGACACAAATATCTGCATTGATATGATTCGAAAGCCGCAAAGCAGGGCACTGGCTCATATTCAGCA
ATACCGGCCGGGCGATATCGCTATCTCGGCAATTACGCTGGCAGAGCTTGAATTCGGCGTACAAAAAAGCTCCGATCCCG
CTCGGAATACTCTTCTGCTCATAAAGGCGTGCAGTGTACTGGAAATCCTGCCGTTCGACAATGACGCTGCAGCGGCCTAT
GGGATCGTCCGGTGTCAACTGGAAAGCAAAGGCACACCCATCGGTCCATTTGACACGCTGATTGCGGCTCACGCCATGTC
GCAAGAGCTGACGCTCGTTACGAATAACATGAAAGAATTCAATCGTATTAAAGACTTGAAAGTCGAAAACTGGATTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8413.56 Da        Isoelectric Point: 4.9984

>AT73113 WP_146683782.1 NZ_CP019646:c2578427-2578197 [Limihaloglobus sulfuriphilus]
MNTAKIFSNGRSQAVRLPKDCRFETNEIGINKIGNAVVLFPLNSGWAPLLEACGKFTDDFMADRGDPSEIDKRDPL

Download         Length: 231 bp

>AT73113 NZ_CP019646:c2578427-2578197 [Limihaloglobus sulfuriphilus]
ATGAATACCGCAAAAATATTTTCGAATGGACGCAGTCAGGCAGTTCGGCTGCCTAAGGATTGCCGGTTTGAAACCAATGA
GATTGGTATCAATAAAATCGGTAATGCCGTTGTTTTATTCCCTCTTAACAGCGGCTGGGCACCCTTGTTAGAAGCCTGCG
GCAAATTCACGGATGATTTTATGGCTGACCGCGGCGACCCATCAGAGATTGACAAACGCGACCCTCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References