Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2450623..2452176 Replicon chromosome
Accession NZ_CP019630
Organism Labrenzia aggregata strain RMAR6-6

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag B0E33_RS11410 Protein ID WP_077291290.1
Coordinates 2450875..2452176 (+) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag B0E33_RS11405 Protein ID WP_028482377.1
Coordinates 2450623..2450874 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0E33_RS11375 2445794..2446093 + 300 WP_077291286.1 hypothetical protein -
B0E33_RS11380 2446146..2447030 + 885 WP_077293234.1 50S ribosomal protein L15 -
B0E33_RS11390 2448118..2448888 - 771 WP_077291287.1 hypothetical protein -
B0E33_RS11395 2449168..2449599 - 432 WP_077291288.1 hypothetical protein -
B0E33_RS11400 2449612..2450118 - 507 WP_077291289.1 antirestriction protein ArdA -
B0E33_RS11405 2450623..2450874 + 252 WP_028482377.1 helix-turn-helix domain-containing protein Antitoxin
B0E33_RS11410 2450875..2452176 + 1302 WP_077291290.1 type II toxin-antitoxin system HipA family toxin Toxin
B0E33_RS11415 2452317..2453003 - 687 WP_077291291.1 hypothetical protein -
B0E33_RS11420 2453078..2454265 + 1188 WP_077291292.1 hypothetical protein -
B0E33_RS11425 2454265..2455926 + 1662 WP_077291293.1 ThiF family adenylyltransferase -
B0E33_RS11430 2455923..2456387 + 465 WP_077291294.1 Mov34/MPN/PAD-1 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2439365..2462804 23439


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(154-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-66)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48623.61 Da        Isoelectric Point: 6.9101

>T73104 WP_077291290.1 NZ_CP019630:2450875-2452176 [Labrenzia aggregata]
MGRRRSYQPLSVFMNTRHVGTLTRESTGAISFAYDKSWLAWESTMPVSLSLPLRKDRYVGAPVMAVFDNLLPDNDDIRKR
VAERVGAQGTDAYSMLSEIGRDCIGALQFLPEGEEPQATSNLSGEPVSDKQIEEMLNDLDVAPLGIRKERDFRISIAGAQ
EKTALLYHEGQWIEPSGTTPTTHIIKPQIGKLPNGMDLSDSVENEYLCLKLLEAFGLRTANVEMATFGKRKALVIERFDR
RWAKDGRLIRLPQEDCCQLLSIPPTRKYQNEGGPGIVEIIDRLRGSDEPTQDRLDFFKANILFWLMGATDGHAKNFSIAL
MPGGRFRMTPLYDVLTVQPTYDQGQIQRKDFKLAMRFGKSNHYKIENIYGRHILETGVEAGLSKDAVGSLFDELHHDVPK
AIEKTIKELPKGFPAALIDSVQGAISNRLKRLE

Download         Length: 1302 bp

>T73104 NZ_CP019630:2450875-2452176 [Labrenzia aggregata]
ATGGGACGCCGGAGAAGCTATCAACCCTTGAGCGTTTTCATGAATACGCGCCATGTTGGCACGCTTACGCGTGAAAGCAC
GGGCGCCATCAGCTTCGCATATGACAAGAGTTGGCTGGCTTGGGAAAGCACTATGCCCGTTTCCCTTTCCTTGCCCCTTC
GCAAGGATCGGTATGTCGGCGCACCCGTGATGGCCGTATTCGACAACCTGCTTCCAGACAACGACGACATCCGAAAACGC
GTTGCCGAACGCGTCGGTGCCCAGGGCACAGATGCTTACAGTATGCTTTCGGAAATTGGACGTGACTGCATCGGCGCGCT
GCAATTCTTACCGGAAGGAGAAGAACCGCAAGCGACCAGCAATCTGAGCGGAGAACCTGTCAGCGACAAGCAAATCGAAG
AGATGCTAAACGACCTCGATGTTGCGCCTCTGGGTATCCGTAAAGAGAGAGATTTCAGGATTTCCATCGCGGGTGCGCAG
GAAAAAACCGCGCTGCTCTACCATGAAGGCCAATGGATTGAGCCATCGGGAACAACGCCAACAACACACATCATCAAGCC
GCAGATAGGCAAGCTGCCGAACGGCATGGATTTGTCAGACAGCGTTGAAAACGAATATCTGTGCCTGAAACTGCTTGAGG
CATTTGGCTTACGCACAGCCAATGTCGAAATGGCGACGTTCGGAAAACGCAAAGCTCTTGTTATCGAGAGGTTTGATCGT
CGATGGGCGAAGGATGGCCGTCTGATCCGGCTACCGCAAGAAGACTGCTGTCAGTTGCTTTCAATCCCGCCGACAAGAAA
ATACCAAAATGAGGGTGGCCCCGGCATCGTTGAAATTATCGACAGACTGCGCGGGAGTGATGAGCCGACGCAAGATCGGC
TGGACTTTTTCAAAGCAAATATTCTGTTCTGGCTGATGGGCGCGACAGATGGCCATGCGAAGAATTTCAGTATTGCACTT
ATGCCTGGCGGCCGCTTCCGCATGACGCCGCTTTACGACGTGCTAACGGTGCAGCCAACTTATGATCAAGGCCAGATCCA
GCGGAAAGATTTCAAGCTGGCCATGCGCTTTGGCAAATCCAATCATTACAAGATCGAGAACATTTACGGGCGGCATATTC
TCGAAACGGGTGTCGAAGCAGGCTTGTCAAAGGATGCCGTAGGAAGCCTATTCGATGAACTTCATCACGACGTTCCAAAG
GCCATTGAAAAAACGATAAAGGAACTTCCGAAGGGATTTCCGGCTGCTTTGATTGACTCAGTTCAAGGAGCAATTTCAAA
CCGTCTAAAACGGCTAGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9281.68 Da        Isoelectric Point: 10.0883

>AT73104 WP_028482377.1 NZ_CP019630:2450623-2450874 [Labrenzia aggregata]
MKQLARTPKDIGHAIREARKERRLSQTELASRSGLWQETISKIENGVASTKMETLFDVLAALDLEIQVQPRSKGVPSSMD
ALF

Download         Length: 252 bp

>AT73104 NZ_CP019630:2450623-2450874 [Labrenzia aggregata]
ATGAAACAGTTAGCACGAACACCAAAAGATATAGGCCACGCCATTCGTGAAGCACGAAAGGAACGCAGGCTCTCTCAAAC
AGAACTCGCCTCAAGAAGCGGCCTGTGGCAGGAAACCATTTCCAAGATAGAAAACGGCGTAGCGAGCACCAAGATGGAAA
CGCTTTTTGACGTGCTTGCGGCTTTGGATCTTGAGATCCAGGTACAACCCCGCAGTAAGGGTGTGCCGTCCTCTATGGAC
GCGCTGTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References