Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 741616..742533 Replicon chromosome
Accession NZ_CP019626
Organism Bacillus sp. 275

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A807M4S7
Locus tag BZ167_RS03020 Protein ID WP_060674890.1
Coordinates 741616..742362 (+) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag BZ167_RS03025 Protein ID WP_003154807.1
Coordinates 742363..742533 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZ167_RS03000 737008..737958 - 951 WP_031378808.1 ring-cleaving dioxygenase -
BZ167_RS03005 738281..739597 + 1317 WP_007610842.1 amino acid permease -
BZ167_RS03010 739883..740500 + 618 WP_003154804.1 DUF47 domain-containing protein -
BZ167_RS03015 740513..741511 + 999 WP_003154805.1 inorganic phosphate transporter -
BZ167_RS03020 741616..742362 + 747 WP_060674890.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
BZ167_RS03025 742363..742533 + 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
BZ167_RS03030 742790..743668 - 879 WP_060674888.1 N-acetylmuramoyl-L-alanine amidase -
BZ167_RS03035 743682..743945 - 264 WP_003154813.1 phage holin -
BZ167_RS03040 743959..744222 - 264 WP_031378810.1 hemolysin XhlA family protein -
BZ167_RS03045 744274..745035 - 762 WP_060674886.1 hypothetical protein -
BZ167_RS03050 745092..745289 - 198 WP_012117366.1 XkdX family protein -
BZ167_RS03055 745294..745719 - 426 WP_053573490.1 hypothetical protein -
BZ167_RS03060 745732..747321 - 1590 WP_053573489.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29081.56 Da        Isoelectric Point: 4.7755

>T73057 WP_060674890.1 NZ_CP019626:741616-742362 [Bacillus sp. 275]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGITRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMSDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

>T73057 NZ_CP019626:741616-742362 [Bacillus sp. 275]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCCGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCACCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGTCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT73057 WP_003154807.1 NZ_CP019626:742363-742533 [Bacillus sp. 275]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp

>AT73057 NZ_CP019626:742363-742533 [Bacillus sp. 275]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807M4S7

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References