73027

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2597391..2598016 Replicon chromosome
Accession NZ_CP019613
Organism Mycobacterium tuberculosis strain H112

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag B0W98_RS12610 Protein ID WP_003403218.1
Coordinates 2597615..2598016 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag B0W98_RS12605 Protein ID WP_003403213.1
Coordinates 2597391..2597618 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W98_RS12560 2592484..2592711 + 228 WP_003900974.1 hypothetical protein -
B0W98_RS12570 2592929..2593096 - 168 WP_077385191.1 DUF3800 domain-containing protein -
B0W98_RS12575 2593129..2593326 - 198 WP_003403191.1 hypothetical protein -
B0W98_RS12580 2593406..2594563 - 1158 WP_003898524.1 hypothetical protein -
B0W98_RS12585 2594615..2594836 - 222 WP_003898525.1 DUF4926 domain-containing protein -
B0W98_RS12590 2594978..2595583 + 606 WP_003898526.1 hypothetical protein -
B0W98_RS12595 2595602..2596729 - 1128 WP_174209003.1 hypothetical protein -
B0W98_RS12600 2597244..2597459 - 216 Protein_2381 hypothetical protein -
B0W98_RS12605 2597391..2597618 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
B0W98_RS12610 2597615..2598016 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
B0W98_RS12615 2598145..2598840 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
B0W98_RS12620 2598837..2599328 + 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
B0W98_RS12625 2599325..2600416 + 1092 WP_003900977.1 galactokinase -
B0W98_RS12635 2600811..2601875 + 1065 WP_003898532.1 hypothetical protein -
B0W98_RS12640 2601979..2602926 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T73027 WP_003403218.1 NZ_CP019613:2597615-2598016 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T73027 NZ_CP019613:2597615-2598016 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT73027 WP_003403213.1 NZ_CP019613:2597391-2597618 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT73027 NZ_CP019613:2597391-2597618 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References