73026

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2591898..2592541 Replicon chromosome
Accession NZ_CP019613
Organism Mycobacterium tuberculosis strain H112

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag B0W98_RS12555 Protein ID WP_003403187.1
Coordinates 2592140..2592541 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag B0W98_RS12550 Protein ID WP_003403184.1
Coordinates 2591898..2592143 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W98_RS12510 2587178..2587648 - 471 WP_003403144.1 HAMP domain-containing protein -
B0W98_RS12515 2587692..2588453 - 762 WP_003403148.1 two-component system response regulator TcrA -
B0W98_RS12520 2588510..2588821 + 312 WP_003403164.1 hypothetical protein -
B0W98_RS12525 2588893..2589843 + 951 WP_003900184.1 DUF1259 domain-containing protein -
B0W98_RS12535 2590084..2590668 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
B0W98_RS12540 2590670..2591413 + 744 WP_031657574.1 IS607 family element transposase accessory protein TnpB -
B0W98_RS12545 2591467..2591853 + 387 WP_003403180.1 hypothetical protein -
B0W98_RS12550 2591898..2592143 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
B0W98_RS12555 2592140..2592541 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
B0W98_RS12560 2592484..2592711 + 228 WP_003900974.1 hypothetical protein -
B0W98_RS12570 2592929..2593096 - 168 WP_077385191.1 DUF3800 domain-containing protein -
B0W98_RS12575 2593129..2593326 - 198 WP_003403191.1 hypothetical protein -
B0W98_RS12580 2593406..2594563 - 1158 WP_003898524.1 hypothetical protein -
B0W98_RS12585 2594615..2594836 - 222 WP_003898525.1 DUF4926 domain-containing protein -
B0W98_RS12590 2594978..2595583 + 606 WP_003898526.1 hypothetical protein -
B0W98_RS12595 2595602..2596729 - 1128 WP_174209003.1 hypothetical protein -
B0W98_RS12600 2597244..2597459 - 216 Protein_2381 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T73026 WP_003403187.1 NZ_CP019613:2592140-2592541 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T73026 NZ_CP019613:2592140-2592541 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT73026 WP_003403184.1 NZ_CP019613:2591898-2592143 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT73026 NZ_CP019613:2591898-2592143 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References