73024

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 2583493..2584139 Replicon chromosome
Accession NZ_CP019613
Organism Mycobacterium tuberculosis strain H112

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag B0W98_RS12480 Protein ID WP_003403122.1
Coordinates 2583493..2583885 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag B0W98_RS12485 Protein ID WP_003403125.1
Coordinates 2583882..2584139 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W98_RS12465 2579155..2580681 + 1527 WP_003403112.1 virulence factor Mce family protein -
B0W98_RS12470 2580678..2581886 + 1209 WP_003403114.1 virulence factor Mce family protein -
B0W98_RS12475 2581891..2583441 + 1551 WP_003905349.1 MCE family protein -
B0W98_RS12480 2583493..2583885 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
B0W98_RS12485 2583882..2584139 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
B0W98_RS12490 2584322..2585557 - 1236 WP_003403128.1 ATP-binding protein -
B0W98_RS12495 2585808..2586221 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
B0W98_RS12500 2586218..2586454 - 237 WP_003403139.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
B0W98_RS12505 2586558..2587064 - 507 WP_003900973.1 two component system sensor kinase HK1 -
B0W98_RS12510 2587178..2587648 - 471 WP_003403144.1 HAMP domain-containing protein -
B0W98_RS12515 2587692..2588453 - 762 WP_003403148.1 two-component system response regulator TcrA -
B0W98_RS12520 2588510..2588821 + 312 WP_003403164.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T73024 WP_003403122.1 NZ_CP019613:c2583885-2583493 [Mycobacterium tuberculosis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

>T73024 NZ_CP019613:c2583885-2583493 [Mycobacterium tuberculosis]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT73024 WP_003403125.1 NZ_CP019613:c2584139-2583882 [Mycobacterium tuberculosis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp

>AT73024 NZ_CP019613:c2584139-2583882 [Mycobacterium tuberculosis]
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References