Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 2251929..2252455 Replicon chromosome
Accession NZ_CP019613
Organism Mycobacterium tuberculosis strain H112

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag B0W98_RS10915 Protein ID WP_003401560.1
Coordinates 2252153..2252455 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID -
Locus tag B0W98_RS10910 Protein ID WP_031665974.1
Coordinates 2251929..2252156 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W98_RS10895 2247622..2248425 - 804 WP_003401540.1 hypothetical protein -
B0W98_RS10900 2248435..2249832 - 1398 WP_112741598.1 sulfatase -
B0W98_RS10905 2250011..2251786 + 1776 WP_010886074.1 PE family protein -
B0W98_RS10910 2251929..2252156 + 228 WP_031665974.1 ribbon-helix-helix protein, CopG family Antitoxin
B0W98_RS10915 2252153..2252455 + 303 WP_003401560.1 toxin-antitoxin system toxin Toxin
B0W98_RS10920 2252503..2252724 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 -
B0W98_RS10925 2252721..2253146 + 426 WP_003401566.1 PIN domain nuclease -
B0W98_RS10930 2253282..2253914 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
B0W98_RS10935 2253911..2254819 + 909 WP_003900117.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-40)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10442.16 Da        Isoelectric Point: 4.9609

>T73018 WP_003401560.1 NZ_CP019613:2252153-2252455 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

>T73018 NZ_CP019613:2252153-2252455 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8148.24 Da        Isoelectric Point: 7.0084

>AT73018 WP_031665974.1 NZ_CP019613:2251929-2252156 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHMRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Download         Length: 228 bp

>AT73018 NZ_CP019613:2251929-2252156 [Mycobacterium tuberculosis]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACATGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGAGCGGCCGGAAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References