73012

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1180419..1181093 Replicon chromosome
Accession NZ_CP019613
Organism Mycobacterium tuberculosis strain H112

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag B0W98_RS05985 Protein ID WP_003417282.1
Coordinates 1180419..1180847 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag B0W98_RS05990 Protein ID WP_003417286.1
Coordinates 1180851..1181093 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W98_RS05960 1176241..1176642 - 402 WP_003417264.1 cytidine deaminase -
B0W98_RS05965 1176783..1177217 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
B0W98_RS05970 1177214..1177648 + 435 WP_003902441.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
B0W98_RS05975 1177777..1179549 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
B0W98_RS05980 1179549..1180340 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
B0W98_RS05985 1180419..1180847 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
B0W98_RS05990 1180851..1181093 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
B0W98_RS05995 1181215..1181829 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
B0W98_RS06000 1181826..1182491 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
B0W98_RS06005 1182492..1183025 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
B0W98_RS06010 1183022..1183396 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
B0W98_RS06020 1185001..1185162 + 162 WP_009937401.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T73012 WP_003417282.1 NZ_CP019613:c1180847-1180419 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T73012 NZ_CP019613:c1180847-1180419 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT73012 WP_003417286.1 NZ_CP019613:c1181093-1180851 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT73012 NZ_CP019613:c1181093-1180851 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References