73002

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 407484..408198 Replicon chromosome
Accession NZ_CP019613
Organism Mycobacterium tuberculosis strain H112

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag B0W98_RS02040 Protein ID WP_003413460.1
Coordinates 407758..408198 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag B0W98_RS02035 Protein ID WP_003413456.1
Coordinates 407484..407771 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W98_RS02000 402906..403151 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
B0W98_RS02005 403148..403552 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
B0W98_RS02010 403769..404389 + 621 WP_057359058.1 DUF4178 domain-containing protein -
B0W98_RS02015 404400..404894 + 495 WP_003413444.1 DUF2617 family protein -
B0W98_RS02020 404891..405322 + 432 WP_003899390.1 DUF4247 domain-containing protein -
B0W98_RS02025 405404..405805 + 402 WP_003899391.1 DUF350 domain-containing protein -
B0W98_RS02030 405802..407373 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
B0W98_RS02035 407484..407771 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
B0W98_RS02040 407758..408198 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
B0W98_RS02045 408219..408974 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
B0W98_RS02050 409107..409703 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
B0W98_RS02055 409711..410556 - 846 WP_003413466.1 acyl-CoA thioesterase II -
B0W98_RS02060 410585..411484 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
B0W98_RS02065 411612..412286 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T73002 WP_003413460.1 NZ_CP019613:407758-408198 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T73002 NZ_CP019613:407758-408198 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT73002 WP_003413456.1 NZ_CP019613:407484-407771 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT73002 NZ_CP019613:407484-407771 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References