72999

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 345575..346284 Replicon chromosome
Accession NZ_CP019613
Organism Mycobacterium tuberculosis strain H112

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag B0W98_RS01735 Protein ID WP_003413164.1
Coordinates 345575..345988 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag B0W98_RS01740 Protein ID WP_003413167.1
Coordinates 346027..346284 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W98_RS01700 340629..341834 - 1206 WP_003413027.1 chorismate synthase -
B0W98_RS01705 341849..342256 + 408 WP_003413029.1 hypothetical protein -
B0W98_RS01710 342552..343763 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
B0W98_RS01720 343890..344549 + 660 WP_003902296.1 hypothetical protein -
B0W98_RS01725 344546..345208 + 663 WP_003905878.1 hypothetical protein -
B0W98_RS01730 345205..345482 + 278 Protein_318 type II toxin-antitoxin system VapB family antitoxin -
B0W98_RS01735 345575..345988 + 414 WP_003413164.1 PIN domain nuclease Toxin
B0W98_RS01740 346027..346284 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
B0W98_RS01745 346281..346658 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
B0W98_RS01750 346674..347048 - 375 WP_003413177.1 hypothetical protein -
B0W98_RS01755 347148..347543 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
B0W98_RS01760 347540..347785 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
B0W98_RS01770 348196..348615 - 420 WP_003413190.1 A24 family peptidase -
B0W98_RS01775 348627..349436 - 810 WP_003413193.1 shikimate dehydrogenase -
B0W98_RS01780 349433..350686 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
B0W98_RS01785 350679..351191 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T72999 WP_003413164.1 NZ_CP019613:345575-345988 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T72999 NZ_CP019613:345575-345988 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT72999 WP_003413167.1 NZ_CP019613:346027-346284 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT72999 NZ_CP019613:346027-346284 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References