Detailed information of TA system TA072995

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 3696974..3697680
• Replicon: chromosome
• Accession: NZ_CP019612
• Organism: Mycobacterium tuberculosis strain H107

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: B0W96_RS18050
• Protein ID: WP_060815814.1
• Coordinates: 3697270..3697680 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P9WF23
• Locus tag: B0W96_RS18045
• Protein ID: WP_003417995.1
• Coordinates: 3696974..3697273 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B0W96_RS18025	3692984..3694585	-	1602	WP_003417969.1	FAD/NAD(P)-binding protein	-
B0W96_RS18030	3694602..3695306	-	705	WP_003417980.1	dTDP-4-amino-4,6-dideoxyglucose formyltransferase	-
B0W96_RS18035	3695424..3695990	-	567	WP_003417984.1	TetR/AcrR family transcriptional regulator	-
B0W96_RS18040	3696052..3696939	+	888	WP_003900050.1	alpha-ketoglutarate-dependent sulfate ester dioxygenase	-
B0W96_RS18045	3696974..3697273	+	300	WP_003417995.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
B0W96_RS18050	3697270..3697680	+	411	WP_060815814.1	type II toxin-antitoxin system VapC family toxin	Toxin
B0W96_RS18055	3697713..3699449	-	1737	WP_003418002.1	cholesterol oxidase	-
B0W96_RS18060	3699505..3700632	-	1128	WP_003418005.1	GuaB3 family IMP dehydrogenase-related protein	-
B0W96_RS18065	3700652..3702241	-	1590	WP_003900682.1	IMP dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-61)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14794.97 Da
• Isoelectric Point: 5.7411

>T72995 WP_060815814.1 NZ_CP019612:3697270-3697680 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSRQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Nucleotide

• Length: 411 bp

>T72995 NZ_CP019612:3697270-3697680 [Mycobacterium tuberculosis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCCGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11009.66 Da
• Isoelectric Point: 10.7399

>AT72995 WP_003417995.1 NZ_CP019612:3696974-3697273 [Mycobacterium tuberculosis]
MRATVGLVEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEP
ARGRKRTLSDVLNEMRDEQ

Nucleotide

• Length: 300 bp

>AT72995 NZ_CP019612:3696974-3697273 [Mycobacterium tuberculosis]
ATGCGTGCTACCGTTGGGCTTGTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGT
TGAAGCCGGCGAGGAACTTGGCGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTT
CTCGCGAAGCCCTGATTGAATCAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCG
GCGCGCGGCCGCAAGCGCACCCTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A045H9T3