Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2975680..2976208 Replicon chromosome
Accession NZ_CP019612
Organism Mycobacterium tuberculosis strain H107

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag B0W96_RS14670 Protein ID WP_044108447.1
Coordinates 2975680..2975994 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag B0W96_RS14675 Protein ID WP_003901465.1
Coordinates 2975978..2976208 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W96_RS14650 2971090..2972778 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
B0W96_RS14655 2972782..2973108 - 327 WP_003414157.1 hypothetical protein -
B0W96_RS14660 2973239..2973868 + 630 WP_003414158.1 DUF3558 family protein -
B0W96_RS14665 2973887..2975536 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
B0W96_RS14670 2975680..2975994 - 315 WP_044108447.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
B0W96_RS14675 2975978..2976208 - 231 WP_003901465.1 antitoxin MazE Antitoxin
B0W96_RS14680 2976251..2977293 - 1043 Protein_2782 DUF2293 domain-containing protein -
B0W96_RS14685 2977484..2977759 + 276 WP_003911993.1 DUF1778 domain-containing protein -
B0W96_RS21630 2977935..2978189 - 255 WP_003917684.1 hypothetical protein -
B0W96_RS14695 2978337..2978741 + 405 WP_009938577.1 hypothetical protein -
B0W96_RS14700 2978738..2978929 + 192 WP_003414184.1 hypothetical protein -
B0W96_RS14705 2979128..2980282 + 1155 WP_003899488.1 DDE-type integrase/transposase/recombinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11195.82 Da        Isoelectric Point: 10.7779

>T72986 WP_044108447.1 NZ_CP019612:c2975994-2975680 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELA

Download         Length: 315 bp

>T72986 NZ_CP019612:c2975994-2975680 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT72986 WP_003901465.1 NZ_CP019612:c2976208-2975978 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT72986 NZ_CP019612:c2976208-2975978 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7DU5
PDB 6KYT
AlphaFold DB A0A7U4FBW3

References