Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2271666..2272195 Replicon chromosome
Accession NZ_CP019612
Organism Mycobacterium tuberculosis strain H107

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag B0W96_RS11030 Protein ID WP_003411124.1
Coordinates 2271666..2271983 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag B0W96_RS11035 Protein ID WP_003411127.1
Coordinates 2271980..2272195 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W96_RS11000 2266803..2267879 + 1077 WP_003411110.1 hypothetical protein -
B0W96_RS11005 2267876..2268157 + 282 WP_003411112.1 hypothetical protein -
B0W96_RS11010 2268193..2269266 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
B0W96_RS11015 2269271..2269801 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
B0W96_RS11020 2269849..2271195 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
B0W96_RS11030 2271666..2271983 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B0W96_RS11035 2271980..2272195 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
B0W96_RS11040 2272450..2273508 + 1059 WP_003411129.1 hypothetical protein -
B0W96_RS11045 2273638..2273994 - 357 WP_003411130.1 hypothetical protein -
B0W96_RS11050 2274089..2274871 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
B0W96_RS11055 2275139..2275429 - 291 WP_003900476.1 YggT family protein -
B0W96_RS11060 2275591..2276247 - 657 WP_003411133.1 cell division protein SepF -
B0W96_RS11065 2276313..2277089 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T72976 WP_003411124.1 NZ_CP019612:c2271983-2271666 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T72976 NZ_CP019612:c2271983-2271666 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT72976 WP_003411127.1 NZ_CP019612:c2272195-2271980 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT72976 NZ_CP019612:c2272195-2271980 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References