Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2068139..2068683 | Replicon | chromosome |
| Accession | NZ_CP019612 | ||
| Organism | Mycobacterium tuberculosis strain H107 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | B0W96_RS10020 | Protein ID | WP_003409896.1 |
| Coordinates | 2068139..2068435 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | B0W96_RS10025 | Protein ID | WP_003409899.1 |
| Coordinates | 2068432..2068683 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| B0W96_RS09965 | 2063172..2063522 | - | 351 | WP_003899096.1 | hypothetical protein | - |
| B0W96_RS09970 | 2063533..2064435 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| B0W96_RS09975 | 2064456..2064647 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| B0W96_RS09980 | 2064648..2064944 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| B0W96_RS09985 | 2065184..2065399 | + | 216 | WP_003409878.1 | antitoxin | - |
| B0W96_RS09990 | 2065396..2065707 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| B0W96_RS21590 | 2065681..2066202 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| B0W96_RS10000 | 2066177..2066554 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| B0W96_RS10005 | 2066596..2067045 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| B0W96_RS10010 | 2067042..2067587 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| B0W96_RS10015 | 2067476..2068090 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| B0W96_RS10020 | 2068139..2068435 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| B0W96_RS10025 | 2068432..2068683 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| B0W96_RS10030 | 2068670..2069164 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| B0W96_RS10035 | 2069324..2069731 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| B0W96_RS10040 | 2069735..2070007 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| B0W96_RS10045 | 2070040..2071260 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| B0W96_RS10060 | 2072159..2072956 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T72968 WP_003409896.1 NZ_CP019612:c2068435-2068139 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T72968 NZ_CP019612:c2068435-2068139 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT72968 WP_003409899.1 NZ_CP019612:c2068683-2068432 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT72968 NZ_CP019612:c2068683-2068432 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |