72963

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1639672..1640300 Replicon chromosome
Accession NZ_CP019612
Organism Mycobacterium tuberculosis strain H107

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag B0W96_RS07990 Protein ID WP_003407786.1
Coordinates 1639896..1640300 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WLU3
Locus tag B0W96_RS07985 Protein ID WP_003407785.1
Coordinates 1639672..1639890 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W96_RS07955 1635092..1635472 + 381 WP_003407768.1 fumarate reductase subunit C -
B0W96_RS07960 1635469..1635846 + 378 WP_003407771.1 fumarate reductase subunit FrdD -
B0W96_RS07965 1635914..1636522 + 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
B0W96_RS07970 1636661..1637854 + 1194 WP_003901197.1 MMPL family transporter -
B0W96_RS07975 1637864..1638310 + 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
B0W96_RS07980 1638345..1639634 + 1290 WP_003407781.1 threonine ammonia-lyase -
B0W96_RS07985 1639672..1639890 + 219 WP_003407785.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
B0W96_RS07990 1639896..1640300 + 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
B0W96_RS07995 1640317..1642059 - 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
B0W96_RS08000 1642052..1644349 - 2298 WP_003407790.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(7-49)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T72963 WP_003407786.1 NZ_CP019612:1639896-1640300 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

>T72963 NZ_CP019612:1639896-1640300 [Mycobacterium tuberculosis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8209.32 Da        Isoelectric Point: 4.5600

>AT72963 WP_003407785.1 NZ_CP019612:1639672-1639890 [Mycobacterium tuberculosis]
VYRWCMSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 219 bp

>AT72963 NZ_CP019612:1639672-1639890 [Mycobacterium tuberculosis]
GTGTATCGTTGGTGTATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCT
GACCACCAAGAGGGCGGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGC
TGGAAGGCGTCGGCTGGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB P9WLU3

References