Detailed information of TA system TA072940

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 319105..320116
• Replicon: chromosome
• Accession: NZ_CP019612
• Organism: Mycobacterium tuberculosis strain H107

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: L7N5R2
• Locus tag: B0W96_RS01375
• Protein ID: WP_003401859.1
• Coordinates: 319105..319698 (-)
• Length: 198 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: B0W96_RS01380
• Protein ID: WP_112612149.1
• Coordinates: 319727..320116 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B0W96_RS01355	314754..316136	+	1383	WP_003898415.1	magnesium transporter	-
B0W96_RS01360	316148..317182	-	1035	WP_003401856.1	class II fructose-bisphosphate aldolase	-
B0W96_RS01365	317278..317961	+	684	WP_003401857.1	VTT domain-containing protein	-
B0W96_RS01370	317950..319080	-	1131	WP_003401858.1	hypothetical protein	-
B0W96_RS01375	319105..319698	-	594	WP_003401859.1	zeta toxin family protein	Toxin
B0W96_RS01380	319727..320116	-	390	WP_112612149.1	hypothetical protein	Antitoxin
B0W96_RS01385	320197..321408	-	1212	WP_003906353.1	VWA domain-containing protein	-
B0W96_RS01390	321414..322016	-	603	WP_003898417.1	SRPBCC family protein	-
B0W96_RS01395	322030..322926	-	897	WP_003898418.1	MoxR family ATPase	-
B0W96_RS01400	322923..323516	-	594	WP_003401864.1	NTP transferase domain-containing protein	-
B0W96_RS01405	323513..324268	-	756	WP_003401865.1	XdhC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-156)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 198 a.a.
• Molecular weight: 21344.53 Da
• Isoelectric Point: 10.5018

>T72940 WP_003401859.1 NZ_CP019612:c319698-319105 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Nucleotide

• Length: 594 bp

>T72940 NZ_CP019612:c319698-319105 [Mycobacterium tuberculosis]
GTGAAGCGGCTCGATCTGGTCGCCGGGCCCAACGGCGCCGGCAAGTCGACGTTCGTCGCCCTCACGCTGGCGCCCTTGCT
GCCCGGCATCGTCTTCGTCAACGCCGACGAAATCGCCAAACAACGCTGGCCCGACGACCCAACATCGCACGCCTACCAGG
CGGCGCAGGTCGCCGCCGACACCCGCGCGAGGCTCATCGACTTGGGCCGGCCGTTCATTGCCGAGACGGTGTTCTCGCAC
CCATCGAAGCTCGAGCTCATCCGCACCGCGCGCACGGCCGGCTACACCGTCGTACTGCACGTGTTGGTTATCCCCGAAGG
CCTGGCGGTCGAGCGCGTCAGGCATCGCGTCGCCGCGGGCGGCCACGATGTGCCGGAGACCAAGATCCGCGAGCGTCACC
GCCGGCTGGCCGAGCTTGTCGCCCAGGCCATCACGCTGGCCGACGGCGCCACCGTCTATGACAACAGCCGGCTCGCGGGC
CCGCGGATCGTCGCTCAGTTCAGCGGGGGTGGCATCATCGGGCGCGCATGCTGGCCTTCGTGGACGCCGCCACCCTTGAT
GTCACGCTGGAGTAACAGGCCTGAGACGGCGTAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13634.14 Da
• Isoelectric Point: 5.5850

>AT72940 WP_112612149.1 NZ_CP019612:c320116-319727 [Mycobacterium tuberculosis]
VPNAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Nucleotide

• Length: 390 bp

>AT72940 NZ_CP019612:c320116-319727 [Mycobacterium tuberculosis]
GTGCCCAACGCCGTCGACCGCGTCACGCGCGTCGCCGCGGATCTGGTGGACAGCGCGGCGGCCGAGGGTGCTCGTCAGAG
CCGTTCGGCCAAGCAGCAGCTCGACCACTGGGCCCGCGTCGGTCGGGCGGTGTCGAACCAGCACACGGCGTCGCGGCGCC
GCGTGGAAGCTGCGCTCGCGGGGCATCTGCCGATGACGGACCTGACGCTGGAGGAGGGCGTGGTGTTCAACGCCGAGATC
TCCGCAGCTATCGAGGAGCGCCTGTCGCGAACCAACTACGGCGACGTGCTCGCCGCGCAGGGCATCACCACGGTCGCCCT
GAACGACGCGGGCGACATCGTCGAGCACCGGCCAGACGGCACCTCGGTCGTGCTGGCGGCCACGCCGTGA

Structures

Toxin

• AlphaFold DB: A0A7U4BRU8