Detailed information of TA system TA072936

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 206521..207155
• Replicon: chromosome
• Accession: NZ_CP019612
• Organism: Mycobacterium tuberculosis strain H107

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WF84
• Locus tag: B0W96_RS00910
• Protein ID: WP_003401406.1
• Coordinates: 206521..206949 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: B0W96_RS00915
• Protein ID: WP_011961607.1
• Coordinates: 206973..207155 (-)
• Length: 61 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B0W96_RS00885	202388..203521	-	1134	WP_003401394.1	hypothetical protein	-
B0W96_RS00890	203518..204138	-	621	WP_003401397.1	TetR/AcrR family transcriptional regulator	-
B0W96_RS00895	204235..204816	+	582	WP_003401399.1	VOC family protein	-
B0W96_RS00900	204746..205471	-	726	WP_003899886.1	TetR/AcrR family transcriptional regulator	-
B0W96_RS00905	205561..206481	+	921	WP_003401404.1	DUF2236 domain-containing protein	-
B0W96_RS00910	206521..206949	-	429	WP_003401406.1	type II toxin-antitoxin system VapC family toxin	Toxin
B0W96_RS00915	206973..207155	-	183	WP_011961607.1	hypothetical protein	Antitoxin
B0W96_RS00920	207250..210057	-	2808	WP_025202582.1	PE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-133)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15887.27 Da
• Isoelectric Point: 7.2214

>T72936 WP_003401406.1 NZ_CP019612:c206949-206521 [Mycobacterium tuberculosis]
MFLIDVNVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLTTNRRIFEIPSPRADAFAFVEAVNAQPHHL
PTSPGPRHLVLLRKLCDEADASGDLIPDAVLGAIAVEHHCAVVSLDRDFARFASVRHIRPPI

Nucleotide

• Length: 429 bp

>T72936 NZ_CP019612:c206949-206521 [Mycobacterium tuberculosis]
ATGTTCCTCATCGACGTCAACGTGCTGCTGGCTGCACACCGCGGTGACCATCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTTGCGGCCGACGACCCCTTCACAGTGCCGAACCTAGTGTGGGCGTCGTTCCTCCGGCTAACAACGAATC
GACGCATCTTCGAGATTCCGTCACCACGAGCGGATGCATTCGCATTCGTCGAAGCCGTCAACGCCCAGCCCCATCACCTT
CCGACAAGCCCCGGCCCCAGACACCTGGTGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGGGGCCATCGCCGTGGAGCATCACTGCGCCGTGGTGAGCCTGGATAGGGATTTCGCCCGGTTTGCCT
CTGTGCGCCATATTCGCCCGCCAATCTAG

Antitoxin

Protein

• Length: 61 a.a.
• Molecular weight: 6262.06 Da
• Isoelectric Point: 4.5878

>AT72936 WP_011961607.1 NZ_CP019612:c207155-206973 [Mycobacterium tuberculosis]
MGAVIEDALRRELAAARTGGARPTVPVFDAGTGPRPGIDLTSNTVLSEVLDEGLELNSRK

Nucleotide

• Length: 183 bp

>AT72936 NZ_CP019612:c207155-206973 [Mycobacterium tuberculosis]
CTGGGCGCTGTGATCGAAGACGCCCTTCGGCGGGAGCTCGCCGCCGCCCGTACCGGCGGCGCCCGGCCAACCGTCCCCGT
TTTTGACGCCGGCACCGGTCCGCGGCCAGGTATCGACCTAACCTCGAATACGGTGTTGTCCGAAGTGCTCGACGAGGGTC
TGGAACTGAACTCGCGGAAGTGA

Structures

Toxin

• AlphaFold DB: A0A7U4BRM6