Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3710357..3711071 Replicon chromosome
Accession NZ_CP019611
Organism Mycobacterium tuberculosis strain H83

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag B0W95_RS17885 Protein ID WP_003413460.1
Coordinates 3710631..3711071 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag B0W95_RS17880 Protein ID WP_003413456.1
Coordinates 3710357..3710644 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W95_RS17845 3705779..3706024 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
B0W95_RS17850 3706021..3706425 + 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
B0W95_RS17855 3706642..3707262 + 621 WP_003413441.1 DUF4178 domain-containing protein -
B0W95_RS17860 3707273..3707767 + 495 WP_003413444.1 DUF2617 family protein -
B0W95_RS17865 3707764..3708195 + 432 WP_003899390.1 DUF4247 domain-containing protein -
B0W95_RS17870 3708277..3708678 + 402 WP_003899391.1 DUF350 domain-containing protein -
B0W95_RS17875 3708675..3710246 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
B0W95_RS17880 3710357..3710644 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
B0W95_RS17885 3710631..3711071 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
B0W95_RS17890 3711092..3711847 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
B0W95_RS17895 3711980..3712576 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
B0W95_RS17900 3712584..3713429 - 846 WP_003413466.1 acyl-CoA thioesterase II -
B0W95_RS17905 3713458..3714357 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
B0W95_RS17910 3714485..3715159 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T72926 WP_003413460.1 NZ_CP019611:3710631-3711071 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T72926 NZ_CP019611:3710631-3711071 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT72926 WP_003413456.1 NZ_CP019611:3710357-3710644 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT72926 NZ_CP019611:3710357-3710644 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References