Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 3191821..3192350 Replicon chromosome
Accession NZ_CP019611
Organism Mycobacterium tuberculosis strain H83

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag B0W95_RS15350 Protein ID WP_003411124.1
Coordinates 3191821..3192138 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag B0W95_RS15355 Protein ID WP_003411127.1
Coordinates 3192135..3192350 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W95_RS15320 3186842..3187918 + 1077 WP_003411110.1 hypothetical protein -
B0W95_RS15325 3187915..3188196 + 282 WP_003411112.1 hypothetical protein -
B0W95_RS15330 3188232..3189305 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
B0W95_RS15335 3189310..3189840 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
B0W95_RS15340 3189888..3191234 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
B0W95_RS15350 3191821..3192138 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B0W95_RS15355 3192135..3192350 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
B0W95_RS15360 3192605..3193663 + 1059 WP_003411129.1 hypothetical protein -
B0W95_RS15365 3193793..3194149 - 357 WP_003411130.1 hypothetical protein -
B0W95_RS15370 3194244..3195026 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
B0W95_RS15375 3195294..3195584 - 291 WP_003900476.1 YggT family protein -
B0W95_RS15380 3195746..3196402 - 657 WP_015456354.1 cell division protein SepF -
B0W95_RS15385 3196468..3197244 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T72920 WP_003411124.1 NZ_CP019611:c3192138-3191821 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T72920 NZ_CP019611:c3192138-3191821 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT72920 WP_003411127.1 NZ_CP019611:c3192350-3192135 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT72920 NZ_CP019611:c3192350-3192135 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References