Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1543906..1544539 Replicon chromosome
Accession NZ_CP019611
Organism Mycobacterium tuberculosis strain H83

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag B0W95_RS07265 Protein ID WP_003403365.1
Coordinates 1543906..1544289 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag B0W95_RS07270 Protein ID WP_003403368.1
Coordinates 1544384..1544539 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W95_RS07240 1539198..1539734 + 537 WP_003403341.1 50S ribosomal protein L10 -
B0W95_RS07245 1539771..1540163 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
B0W95_RS07250 1540156..1540851 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
B0W95_RS07255 1540922..1542427 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
B0W95_RS07260 1542508..1543518 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
B0W95_RS07265 1543906..1544289 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
B0W95_RS07270 1544384..1544539 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
B0W95_RS07275 1544615..1545331 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
B0W95_RS07280 1545607..1545915 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
B0W95_RS07285 1545902..1546147 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
B0W95_RS07290 1546257..1546694 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
B0W95_RS07295 1546691..1546945 - 255 WP_003911263.1 antitoxin VapB7 -
B0W95_RS07300 1547059..1549422 + 2364 WP_003898547.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T72893 WP_003403365.1 NZ_CP019611:c1544289-1543906 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T72893 NZ_CP019611:c1544289-1543906 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT72893 WP_003403368.1 NZ_CP019611:c1544539-1544384 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT72893 NZ_CP019611:c1544539-1544384 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References