Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1493633..1494276 Replicon chromosome
Accession NZ_CP019611
Organism Mycobacterium tuberculosis strain H83

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag B0W95_RS06975 Protein ID WP_003403187.1
Coordinates 1493875..1494276 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag B0W95_RS06970 Protein ID WP_003403184.1
Coordinates 1493633..1493878 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W95_RS06935 1488913..1489383 - 471 WP_003403144.1 HAMP domain-containing protein -
B0W95_RS06940 1489427..1490188 - 762 WP_003403148.1 two-component system response regulator TcrA -
B0W95_RS06945 1490245..1490556 + 312 WP_003403164.1 hypothetical protein -
B0W95_RS06950 1490628..1491578 + 951 WP_112704259.1 DUF1259 domain-containing protein -
B0W95_RS06955 1491819..1492403 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
B0W95_RS06960 1492405..1493148 + 744 WP_003403177.1 IS607 family element transposase accessory protein TnpB -
B0W95_RS06965 1493202..1493588 + 387 WP_003403180.1 hypothetical protein -
B0W95_RS06970 1493633..1493878 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
B0W95_RS06975 1493875..1494276 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
B0W95_RS06980 1494219..1494446 + 228 WP_003900974.1 hypothetical protein -
B0W95_RS06990 1494664..1494831 - 168 WP_077385191.1 DUF3800 domain-containing protein -
B0W95_RS06995 1494864..1495061 - 198 WP_003403191.1 hypothetical protein -
B0W95_RS07000 1495141..1496298 - 1158 WP_003898524.1 hypothetical protein -
B0W95_RS07005 1496350..1496571 - 222 WP_003898525.1 DUF4926 domain-containing protein -
B0W95_RS07010 1496713..1497318 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T72889 WP_003403187.1 NZ_CP019611:1493875-1494276 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T72889 NZ_CP019611:1493875-1494276 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT72889 WP_003403184.1 NZ_CP019611:1493633-1493878 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT72889 NZ_CP019611:1493633-1493878 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References