Detailed information of TA system TA072880

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1117740..1118374
• Replicon: chromosome
• Accession: NZ_CP019611
• Organism: Mycobacterium tuberculosis strain H83

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WF84
• Locus tag: B0W95_RS05200
• Protein ID: WP_003401406.1
• Coordinates: 1117740..1118168 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: B0W95_RS05205
• Protein ID: WP_011961607.1
• Coordinates: 1118192..1118374 (-)
• Length: 61 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B0W95_RS05175	1113607..1114740	-	1134	WP_003401394.1	hypothetical protein	-
B0W95_RS05180	1114737..1115357	-	621	WP_003401397.1	TetR/AcrR family transcriptional regulator	-
B0W95_RS05185	1115454..1116035	+	582	WP_003401399.1	VOC family protein	-
B0W95_RS05190	1115965..1116690	-	726	WP_003899886.1	TetR/AcrR family transcriptional regulator	-
B0W95_RS05195	1116780..1117700	+	921	WP_003401404.1	DUF2236 domain-containing protein	-
B0W95_RS05200	1117740..1118168	-	429	WP_003401406.1	type II toxin-antitoxin system VapC family toxin	Toxin
B0W95_RS05205	1118192..1118374	-	183	WP_011961607.1	hypothetical protein	Antitoxin
B0W95_RS05210	1118469..1121276	-	2808	WP_031650790.1	PE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-133)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15887.27 Da
• Isoelectric Point: 7.2214

>T72880 WP_003401406.1 NZ_CP019611:c1118168-1117740 [Mycobacterium tuberculosis]
MFLIDVNVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLTTNRRIFEIPSPRADAFAFVEAVNAQPHHL
PTSPGPRHLVLLRKLCDEADASGDLIPDAVLGAIAVEHHCAVVSLDRDFARFASVRHIRPPI

Nucleotide

• Length: 429 bp

>T72880 NZ_CP019611:c1118168-1117740 [Mycobacterium tuberculosis]
ATGTTCCTCATCGACGTCAACGTGCTGCTGGCTGCACACCGCGGTGACCATCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTTGCGGCCGACGACCCCTTCACAGTGCCGAACCTAGTGTGGGCGTCGTTCCTCCGGCTAACAACGAATC
GACGCATCTTCGAGATTCCGTCACCACGAGCGGATGCATTCGCATTCGTCGAAGCCGTCAACGCCCAGCCCCATCACCTT
CCGACAAGCCCCGGCCCCAGACACCTGGTGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGGGGCCATCGCCGTGGAGCATCACTGCGCCGTGGTGAGCCTGGATAGGGATTTCGCCCGGTTTGCCT
CTGTGCGCCATATTCGCCCGCCAATCTAG

Antitoxin

Protein

• Length: 61 a.a.
• Molecular weight: 6262.06 Da
• Isoelectric Point: 4.5878

>AT72880 WP_011961607.1 NZ_CP019611:c1118374-1118192 [Mycobacterium tuberculosis]
MGAVIEDALRRELAAARTGGARPTVPVFDAGTGPRPGIDLTSNTVLSEVLDEGLELNSRK

Nucleotide

• Length: 183 bp

>AT72880 NZ_CP019611:c1118374-1118192 [Mycobacterium tuberculosis]
CTGGGCGCTGTGATCGAAGACGCCCTTCGGCGGGAGCTCGCCGCCGCCCGTACCGGCGGCGCCCGGCCAACCGTCCCCGT
TTTTGACGCCGGCACCGGTCCGCGGCCAGGTATCGACCTAACCTCGAATACGGTGTTGTCCGAAGTGCTCGACGAGGGTC
TGGAACTGAACTCGCGGAAGTGA

Structures

Toxin

• AlphaFold DB: A0A7U4BRM6