Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 193712..194418 Replicon chromosome
Accession NZ_CP019611
Organism Mycobacterium tuberculosis strain H83

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag B0W95_RS00850 Protein ID WP_003417998.1
Coordinates 194008..194418 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WF23
Locus tag B0W95_RS00845 Protein ID WP_003417995.1
Coordinates 193712..194011 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W95_RS00825 189722..191323 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
B0W95_RS00830 191340..192044 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
B0W95_RS00835 192162..192728 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
B0W95_RS00840 192790..193677 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
B0W95_RS00845 193712..194011 + 300 WP_003417995.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
B0W95_RS00850 194008..194418 + 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
B0W95_RS00855 194451..196187 - 1737 WP_003418002.1 cholesterol oxidase -
B0W95_RS00860 196243..197370 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
B0W95_RS00865 197390..198979 - 1590 WP_003900682.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-61)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T72878 WP_003417998.1 NZ_CP019611:194008-194418 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

>T72878 NZ_CP019611:194008-194418 [Mycobacterium tuberculosis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11009.66 Da        Isoelectric Point: 10.7399

>AT72878 WP_003417995.1 NZ_CP019611:193712-194011 [Mycobacterium tuberculosis]
MRATVGLVEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEP
ARGRKRTLSDVLNEMRDEQ

Download         Length: 300 bp

>AT72878 NZ_CP019611:193712-194011 [Mycobacterium tuberculosis]
ATGCGTGCTACCGTTGGGCTTGTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGT
TGAAGCCGGCGAGGAACTTGGCGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTT
CTCGCGAAGCCCTGATTGAATCAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCG
GCGCGCGGCCGCAAGCGCACCCTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIR9

Antitoxin

Source ID Structure
AlphaFold DB A0A045H9T3

References