Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 166703..167403 Replicon chromosome
Accession NZ_CP019611
Organism Mycobacterium tuberculosis strain H83

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag B0W95_RS00725 Protein ID WP_003417916.1
Coordinates 166703..167095 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WF13
Locus tag B0W95_RS00730 Protein ID WP_003417918.1
Coordinates 167095..167403 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W95_RS00705 162075..163685 - 1611 WP_003417910.1 1-deoxy-D-xylulose-5-phosphate synthase -
B0W95_RS00710 163630..163911 - 282 WP_003914149.1 hypothetical protein -
B0W95_RS00715 163908..164897 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
B0W95_RS00720 164897..165949 - 1053 WP_003900678.1 polyprenyl synthetase family protein -
B0W95_RS00725 166703..167095 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
B0W95_RS00730 167095..167403 - 309 WP_003417918.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
B0W95_RS00735 167582..168923 + 1342 Protein_140 ISNCY family transposase -
B0W95_RS00740 169113..171308 + 2196 WP_010886168.1 PE family protein -
B0W95_RS00745 171379..172251 - 873 WP_003417929.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 168246..168923 677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-64)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T72877 WP_003417916.1 NZ_CP019611:c167095-166703 [Mycobacterium tuberculosis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

>T72877 NZ_CP019611:c167095-166703 [Mycobacterium tuberculosis]
ATGGCGGCCATCTATCTCGACTCGTCCGCGATCGTCAAGCTCGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGAGTGTCGAGTGCCCTTGCGCGCGCGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAAAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGGCCGTGATCGCCCCGTCGTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11030.59 Da        Isoelectric Point: 4.5332

>AT72877 WP_003417918.1 NZ_CP019611:c167403-167095 [Mycobacterium tuberculosis]
MTPTACATVSTMTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEP
LDLDAGVELPSVTLARLREHER

Download         Length: 309 bp

>AT72877 NZ_CP019611:c167403-167095 [Mycobacterium tuberculosis]
ATGACGCCGACCGCTTGTGCTACAGTTAGCACAATGACCTCGGTGGGGGTGCGTGCGCTGCGGCAGCGGGCCAGCGAGCT
GCTGCGCCGAGTCGAGGCCGGCGAGACGATCGAGATCACCGACCGCGGCCGGCCCGTCGCCCTGCTCTCGCCGCTGCCGC
AGGGCGGTCCATACGAGCAGCTGCTGGCAAGCGGCGAGATCGAGCGTGCCACGCTCGACGTCGTTGATCTGCCCGAACCG
CTCGACCTCGACGCGGGCGTCGAGCTGCCGTCGGTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
PDB 6JQY
AlphaFold DB P9WF13

References