Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 139582..140111 Replicon chromosome
Accession NZ_CP019611
Organism Mycobacterium tuberculosis strain H83

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag B0W95_RS00595 Protein ID WP_003417760.1
Coordinates 139854..140111 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag B0W95_RS00590 Protein ID WP_003417757.1
Coordinates 139582..139857 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W95_RS00555 136155..136949 - 795 WP_003417738.1 BBE domain-containing protein -
B0W95_RS00560 137031..137402 - 372 WP_003417739.1 FAD-binding oxidoreductase -
B0W95_RS21470 137300..137518 - 219 WP_157132559.1 hypothetical protein -
B0W95_RS00570 137545..137805 - 261 WP_003417741.1 hypothetical protein -
B0W95_RS00575 137920..138309 + 390 WP_003417745.1 DUF732 domain-containing protein -
B0W95_RS00580 138323..138616 - 294 WP_003417749.1 DUF3017 domain-containing protein -
B0W95_RS00585 138613..139458 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
B0W95_RS00590 139582..139857 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
B0W95_RS00595 139854..140111 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
B0W95_RS00600 140153..141343 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
B0W95_RS00605 141460..141828 + 369 WP_003417765.1 FHA domain-containing protein -
B0W95_RS00610 141825..142376 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
B0W95_RS00615 142383..142964 - 582 WP_003417769.1 ATP/GTP-binding protein -
B0W95_RS00620 142945..143313 - 369 WP_003417772.1 DUF742 domain-containing protein -
B0W95_RS00625 143291..143683 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T72876 WP_003417760.1 NZ_CP019611:139854-140111 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T72876 NZ_CP019611:139854-140111 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT72876 WP_003417757.1 NZ_CP019611:139582-139857 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT72876 NZ_CP019611:139582-139857 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References