Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4033782..4034496 Replicon chromosome
Accession NZ_CP019610
Organism Mycobacterium tuberculosis strain H54

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag B0W97_RS19695 Protein ID WP_003413460.1
Coordinates 4033782..4034222 (-) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag B0W97_RS19700 Protein ID WP_003413456.1
Coordinates 4034209..4034496 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W97_RS19670 4029694..4030368 - 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -
B0W97_RS19675 4030496..4031395 + 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
B0W97_RS19680 4031424..4032269 + 846 WP_003413466.1 acyl-CoA thioesterase II -
B0W97_RS19685 4032277..4032873 + 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
B0W97_RS19690 4033006..4033761 + 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
B0W97_RS19695 4033782..4034222 - 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
B0W97_RS19700 4034209..4034496 - 288 WP_003413456.1 antitoxin VapB41 Antitoxin
B0W97_RS19705 4034607..4036178 - 1572 WP_003899392.1 polyamine aminopropyltransferase -
B0W97_RS19710 4036175..4036576 - 402 WP_003899391.1 DUF350 domain-containing protein -
B0W97_RS19715 4036658..4037089 - 432 WP_003899390.1 DUF4247 domain-containing protein -
B0W97_RS19720 4037086..4037580 - 495 WP_003413444.1 DUF2617 family protein -
B0W97_RS19725 4037591..4038211 - 621 WP_003413441.1 DUF4178 domain-containing protein -
B0W97_RS19730 4038428..4038832 - 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
B0W97_RS19735 4038829..4039074 - 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T72869 WP_003413460.1 NZ_CP019610:c4034222-4033782 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T72869 NZ_CP019610:c4034222-4033782 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT72869 WP_003413456.1 NZ_CP019610:c4034496-4034209 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT72869 NZ_CP019610:c4034496-4034209 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References