Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1840768..1841411 Replicon chromosome
Accession NZ_CP019610
Organism Mycobacterium tuberculosis strain H54

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag B0W97_RS09120 Protein ID WP_003403187.1
Coordinates 1840768..1841169 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag B0W97_RS09125 Protein ID WP_003403184.1
Coordinates 1841166..1841411 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W97_RS09085 1837726..1838331 - 606 WP_003898526.1 hypothetical protein -
B0W97_RS09090 1838473..1838694 + 222 WP_003898525.1 DUF4926 domain-containing protein -
B0W97_RS09095 1838746..1839903 + 1158 WP_003898524.1 hypothetical protein -
B0W97_RS09100 1839983..1840180 + 198 WP_003403191.1 hypothetical protein -
B0W97_RS09105 1840213..1840380 + 168 WP_077385191.1 DUF3800 domain-containing protein -
B0W97_RS09115 1840598..1840825 - 228 WP_003900974.1 hypothetical protein -
B0W97_RS09120 1840768..1841169 - 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
B0W97_RS09125 1841166..1841411 - 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
B0W97_RS09130 1841456..1841842 - 387 WP_003403180.1 hypothetical protein -
B0W97_RS09135 1841896..1842639 - 744 WP_003403177.1 IS607 family element transposase accessory protein TnpB -
B0W97_RS09140 1842641..1843225 - 585 WP_003403171.1 IS607-like element IS1536 family transposase -
B0W97_RS09145 1843466..1844416 - 951 WP_003900184.1 DUF1259 domain-containing protein -
B0W97_RS09150 1844488..1844799 - 312 WP_003403164.1 hypothetical protein -
B0W97_RS09155 1844856..1845617 + 762 WP_003403148.1 two-component system response regulator TcrA -
B0W97_RS09160 1845661..1846131 + 471 WP_003403144.1 HAMP domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T72845 WP_003403187.1 NZ_CP019610:c1841169-1840768 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T72845 NZ_CP019610:c1841169-1840768 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT72845 WP_003403184.1 NZ_CP019610:c1841411-1841166 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT72845 NZ_CP019610:c1841411-1841166 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References