Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1833248..1833873 Replicon chromosome
Accession NZ_CP019610
Organism Mycobacterium tuberculosis strain H54

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag B0W97_RS09055 Protein ID WP_003403218.1
Coordinates 1833248..1833649 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag B0W97_RS09060 Protein ID WP_003403213.1
Coordinates 1833646..1833873 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W97_RS09025 1828338..1829285 - 948 WP_003403232.1 DUF732 domain-containing protein -
B0W97_RS09030 1829389..1830453 - 1065 WP_003898532.1 hypothetical protein -
B0W97_RS09040 1830848..1831939 - 1092 WP_003900977.1 galactokinase -
B0W97_RS09045 1831936..1832427 - 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
B0W97_RS09050 1832424..1833119 - 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
B0W97_RS09055 1833248..1833649 - 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
B0W97_RS09060 1833646..1833873 - 228 WP_003403213.1 antitoxin VapB29 Antitoxin
B0W97_RS09070 1834068..1834310 - 243 WP_003403210.1 hypothetical protein -
B0W97_RS09075 1834307..1835056 - 750 WP_003898528.1 hypothetical protein -
B0W97_RS09080 1835140..1837707 + 2568 WP_003901879.1 SEC-C domain-containing protein -
B0W97_RS09085 1837726..1838331 - 606 WP_003898526.1 hypothetical protein -
B0W97_RS09090 1838473..1838694 + 222 WP_003898525.1 DUF4926 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T72844 WP_003403218.1 NZ_CP019610:c1833649-1833248 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T72844 NZ_CP019610:c1833649-1833248 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT72844 WP_003403213.1 NZ_CP019610:c1833873-1833646 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT72844 NZ_CP019610:c1833873-1833646 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References